https://www.sciencedaily.com/releases/2023/03/230310143648.htm
Some researchers have figured out a minimal catalytic peptide of 13
amino acids that forms a complex with two nickel ions. It is stable and
highly reactive. They think that early proteins may have evolved as
such short peptides with enzymatic activity.
My first science publication involved the regulation of the translation
of alcohol dehydrogenase as part of the anaerobic response, and it
requires nickel as a cofactor. These researchers are proposing that
such hydrogenases could have started out as short peptides.
Ron Okimoto
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