alternate day fasting is published as having the same cardiovascular benefits as calorie restriction
https://www.inverse.com/article/58820-how-is-alternate-day-fasting-different-from-caloric-restriction , with 36 hour fasts and 16 hour eating periods
causing the benefit; This creates the possibility of a number of longevity drugs that are fun to use, possibly nootropic, similar to, or even existing few AMU drugs, and can even be produced with gene therapy: I like the feeling of being on
phenylethylamine for the first 11-14 hours, and it makes it so skipping meals is easy, and I think I have skipped 24 hours of food on it unintentionally.
Longevity causing volunary svelteness drug that increases creativity, productivity, and likely intelligence: An AM time release dose of phenylethylamine that
lasts 14-15 hours until 1 hour before sleep, then 7.5-8 hours of spontaneous sleep, with the previous phenylethylamine time release dose having another AM, until sleep, all day pulsatile dose at waking dose could preclude any daytime hunger for both days,
and be taken once every 24 hours, the person would then eat a lunch dinner or breakfast every 36 hours: the drug could be fine chronological time release as well as molecularly fine tuned to optimize well being, nootropic, successtropic;
phenylethylamine is a euphoric drug that increases my creativity, and I perceive my intelligenece, This molecule, as well as FDA preapproved ADD/ADHD/Narcolespy drugs could also be tested; at phenylethylamine, molecule variations like phenylbutylamine,
phenylpropylamine, as well as partially saturated cycles that range between phenyl group and cyclohexane group could be tested. (mice? circadian?)
Deprenyl is a MAO-B inhibitor that causes greater longevity, and makes people more cheerful, taken with phenylethylamine it causes phenylethylamine to last 200-300 minutes longer, notably though, stacked pulsatile 20-40 minute activity periods are
possible with phenylethylamine when takeing it without an MAO-B inhibitor: deprenyl/other MAO-B inhibitor with PEA: 9 hours effortless calorie restriction PEA only 2 hours, effortless calorie restriction,
PEA only 2 hours, effortless calorie restriction,
Magnesium threonate: Calming nootropic, also a longevizing calming is a possible nootropic
Other molecules that might be fun enough so that people voluntarily take a longevity wellness svelteness drug: halogenated, ethynylized CART peptides or better than CART stimulant peptides that also have a circadian rhythm release effector (peptide
moiety? or, a drug release polymer could get 100 times as diffusive at a .5 degree circadian body warmth shift, like liquid crystal polymers that turn color, or there could be an electret polymer drug that when it changes .05 decrees C or less causes it
to furl or unfurl to have different receptor activating charge and changes biological activity a few orders of magnitude (note, depot injection at cool part of body makes it so the part of the body with the widest degrees C spread, ear tips are a
possibility) The circardian mechanisms at either the CART peptide (or better) depot or the molecule the depot actually contains causes the alternate day caloric restricotion longevity, wellness, fun,
“Better for you than coffee” is a way to communicate the benefits of the fun and productivity part of this longevity wellness, heart disease, cancer preventing drug.
that cause the alternate day fasting calorie restriction like longevity, wellness, body mass enhancement effects could be made into a depot injection or depot implant that lasts over 200 years
depot drugs with multicentury benefits could also have multi hundred times mg/dose effectiveness (nanogram or picogram) effectiveness with drug transport channel optimization, tissue or cyte type localization, Cytes that have just 40, 300, 5000 of some
particular molecular transport channel protein would have hundreds of times greater tissue localization at drugs tyhat have an effect even when absorbed at each cyte’s cytoplasm; alternatively drugs with 40, 300, or 5000 times the activity at efflux
cytomembrane although absorbed at the same velocity might be effluxed 5000 times faster causing much less actual active drug molecule residence moments at the cytoplasm.
gene therapy that ups beneficial metabolizing enzymes at the actual cutoplasm, detoxifying things
nucleur membrane efflux, opposite effluxors, also hyperffluxing tRNA, mRNA could have faster transcription
Phytosomes are a word for liposomes around plant products, it is possible some variety of liposome, like phosphatidylserine as compared with phosphatidylcholine or a different length of alkane the phosphatidyl group has some localization, that variation
in brain (and body) localization from plant based lecithin extracts as a delicious coffee replacement drink could keep the part people like and get rid of the agitation that people find objectionable to where I saw writing with line art comics about.
Also, the people that make it can do more than screening a libary of 20 or 40 GRAS phophatidyl amino acid variants of human volunteers, it could look to phosphatidyl liposome making molecules with high lipophilicity, high hydrophilicity, or high at both
liophilicities; It is even possible that without caffeine agitation the doses could be higher so people get 200-300 mg of up and prosociality and an absence of agitation; I could mention it to LEF.org, they actually already have a beverage product;
Happier, kinder, tremorless, possibly even alert but sleepable 5 hour energy drink, and also organic version.
phosphatidyl 10HDA, screen a library to find a new longevity drug; while this complements liposomes as a technology, it is actually just a fluid that could be taken as a supplement, drug, or as a food additive.
Does piperine attached to the actual molecule cause it to have more blood brain barrier permeation amount, or is is just a coadministration (seperate drug) effect? Drug localization with piperine distal or branched to the localization moeity and the
drug moeity could cause specific neuron active drugs to have only membrane permeation effects at those particular neurons, causing a heightened dose/mg multiplier, absence of nonfocal tissue permeability effects,
crispr gene drive with a molecular cytotransprt peptide transport peptide transport peptide on it first; does it have 100 to 1000 times greater dose/mg effect from preferential transport to the transfected cytes, that could cause 100 to 1000 times
greater vector ability at transfection; also, this could heighten localization at paticular phenotypes as well
network effects at neurons, more ot it than this, but connections per node, causes variation in distribution of node products, so a stable producte high amplitude first deviation highly beneficial nod product could have its number of noides as an
average, adjusted with genetics as well as gene therapy or even drugs to change the distribution histogram math of the network math, a netowrk where a genetic modification or existing gene variation causes such things as the not just the median number
of interconnected neuron neighbors, but the distribution of neightbor interconnections so High-Medium-High is comparable with medium high medium and others at neurons, also the different effects of different neuron interconnectivity distribution networks
is benefically technologyizable, Noting these networks at just one kind of neuron’s kind of beneficial effect getting the amplifaction, compare BDNF
also, network math effects from just 1,2,3, and 30^3 could have much high amplituded of effects than just changing amount of neurptransmitters, amount of circulating nuerotransmitter effecting drug, and quantification of amount of recptors, this makes
neural cyte type localization of network connectivity modifiers have higher bandwidth of discernable effects and higher actusal magnitude (height) of possible effect of modifying neurotransmitters or even neurotransmitter drugs;
During 2019 it is my perception that svelte persons had more spontaneous physical activity than non-svelte persons, so along with the wellness, longevity, healthspan, aesthetic, social factor enhancement heightening from being a svelte person is it also
possible the the greater spontaneous movement and willingness to move cause people to raise their children with more actual active acts, and even a greater quantity of things like hugs and active play, svelteness at parents likely benefits their children.
a researcher found the most similar protein to royalactin in vertebrates/mammals, and called it regina; to make longevity proteins ultraaffordable, could the same homologous gene sequence matching used to find Regina be used to find royalactin-like
proteins as transcribable protein making things at plant genomes? These could then be grown, purified, and tested as to their longevity effects on mice both as orally ingested proteins and enteric coated high availability, non-digested proteins; Plant
sources of 10HDA could also be found this way. Oral ingestion of royal jelly is published at causing mice to live 25 (27%) longer, so there is a possiblility that even digested homologous sequence to royalactin genes’ product could have a longevity
effect even with digestion, this would make genetically engineering it into human foods, animal foods, and perhaps all plants with gene drive to benefit humans and other species.
Does royalactin or 10HDA benefit plants in any way, if they do this could be simultaneously beneficial to the plants and the humans to genetically engineer the production of higher amounts of the
network optimization based on math could be used with many worlds interpretion of physics to make whiter branch universes, notably branch universe groupings, and a possibility of something gooder than a round matrice where any of the combinatorial
additives as well as the component portions, which might be particular MWI universes, the content of those universes that create new branches, and, if and where technologically function, those MWI universes that communicate with other MWI universes, the
combinatorial, or higher
thinking, feeling, and being white causes more MWI universes from a heightened amount of electron, matter, and possibly modellable effect on things physically at greater than 1 micrometer distance from the thinking feeling organism like the most
benevolent human, person, a member of a group of people that is a homo sapiens, notably all living beings with presence of being, isness, that I perceive some people may be called or related to sentience, having white being, moments of thought and
feeling, and actualized white action and behavior and even building cause more MWI universe branches to be generated than from any human thinking or feeling that is not as benevolent, beneficial, simultaneouslu utilitarian
a thing that benefits children: If, or when, children can choose their own parents, including social companion robots,
are there any cytotransport proteins or membrane channels in the oral or nasal mucosa? If there is transport of some peptide, protein, or chemical then Snorting or swishing a thing in your mouth could have 10,100,1000 times the delivered chemical, drug,
or gene therapy dose making it possible to skip the GI tract, also I have noticed that some things cause a kind of mouth pucker, suggesting hydrostatic balance can be modified with harmless things people put in their mouth, anbesol penetrates 3-4mm of
gum tissue in 14 minutes or so, so if some similar molecule works on cheek epithelia at 2 mm in less than 7 minutes (1 mm a minute) that could be a transported chemical; DMSO or an absorption/transport enhanced version of DMSO is likely to function: it
is possible things like diethylsulfoxide or dipropylsulfoxide, or dibranchedlakanesulfoxide could be oil blobs that spill around less, adhere to appliques, while still causing preferential transport of beneficial drugs and chemicals; if the
duoalkanesulfoxide has a long enough alkane it is even possible putting a halogen on it or an ethynyl group could cause some kind of multihundred times increase in transport or physiological activity, so the halogenated ethynylized duoalkanesulfoxide
could be chemically linked, possibly with an enzymatically degradeable linker to an active pharmaceutical drug;
Half to 1/4 cent Gene therapy technology: 3 mm paper circles, perhaps $400 for 12 million or 12 billion of them, each has a flavor attached to a protein, branched protein possible, so the longer it is at saliva the flavor changes through 11 different
flavors, at each flavor 19/20ths of the proteins attached to the flavor chemical are at a certain shape, or have had their branches modified to be a certain shape, the paper circle progresses through all 11 flavors and the person can take the paper
circle out of their moth at any time, defining and making into a gene therapy effect actualization program specifer, the characteristics of the amino acid, which could be a branched amino acid, then after being rinsed in fresh water, which removes the
saliva, the amino acid sequence tells the bacteria that will arise from the bacteria at the paper circle which CRISPR/cas9 sequences to activate at the bacteria, out of the full library of 11 variants at the bacteria; the bacteria have molecular
transport channels engineered to preferentially transport the flavor and color that the human, that is person, that is member of a group of people, that is homo sapiens, has preferred, At the bacteria 19/20 (the amino acid fraction) of the first
generation of bacteria are gene therapy activated modified to be the persons preference, at the next bacterial generation, 19/20th of the other 1/20th are modified to be the gene therapy preference, so then 1/400th of the bacteria are different, then at
the third generation of bacteria, something near 1/9000th of the bacteria have a gene therapy form different than the person’s flavor and color preference, notably I read bacteria reproduce every 20 minutes, with optimization, and a nutrient
environment with things like mitosis stimulants, this could imaginably be 4-7 minutes, so a 16 minute span of bacterial doubling would cuase 8999 out of each 9000 transfection bacteria to be the preferred gene therapy version; Notably the person can
then place the paper dot on their skin, and then have the paper dot’s bacteria do the gene therapy on the person using their skin, I have read about sugar micro projection drug delivery and immunization projections, these could cause the bacteria,
possibly notably the bacteria growing on them, to be delivered deeper to the dermis absent a sensation to the utilizer, also the projections could have a tissue permeabablizing fluid on them like a phospholipid (liposomes are about four times more
effective at some kinds of tissue transport, and a kind of liposome called a phytosome is hundreds of times more effective at transport), it is remotely possible that an anticoagulant, something like DMSO, dermatocyte transport channel activating
chemicals like peptides or proteins on the outside of the liposome that cause active transport, possibly transcytosis, of the bacteria through the dermis to living gene therapy functional dermatocytes, capillary epithelia, and the circulatory system to
occur (although the bacteria could emit CRISPR/cas9 containing single or double stranded DNA or RNA viruses continuously while physically thriving), so that is 300 (sugar divot makers) times 1000 (transport channel proteins or peptides) times 2 (
anticoagulants) times four (DMSO) times 14 (Na PCA causes moist contact surface fourteen times longer) times 2 (the paper circle has anticoagulants to make the contact area particularly aqueous and transmissive, once the bacteria are there they, at non
gene drive areas of the bacterial genome, produce minute amounts of harmless coagulants at each successful mitosis to cause 1/3-1/14 the fluid flow near the growing bacterial colony, reducing immune response to the bacteria 1/3 to 1/14, then 4 times from
harmless to tissue, bacterial hyperproduction of enzymes that if applied separately to the skin, would like youthification chemical peels, actually cause enhanced skin appearance, these cause four times the nutrients to be produced from an appearance
beneficial, harmless to regrowing tissue turning of dermatocytes into bacterial food; four times from tissue seeking bacteria; It is possible that the bacteria, like proteus, could actively swim towards the dermatocytes and seek spaces between cytes to
permeate and seek depth to multiply. Compared with bacteria on the skin, these bacteria at this system (300 times 1000 times 2 times 14 times 2 times 3 times 4, 201 million times more effective at doing gene therapy; it could be possible to multiply
this 201 million with three more powers of two to make the bacteria 1.6 billion times more gene drive vector effective. The combination of 9600 DPI printed circuit electroporation (7 times), DMSO (8 times), and immunotransparent gene therapy bacteria (4
times) causes the 201 million number to go to about 45 billion multiples greater colonization ability than bacteria just placed on the skin; inkjet printed Electroporation geometries and circuits: I think at inkjet printing of 9600 DPI or higher that it
is possible to print electrode metals, dry yet hygroscopic electrolytes and conduction pathways, simple circuits could be printed like dozens or hundreds of arrays of dozens of Mg Ga Zn Ag metal dot patterns at 9600 DPI, and hundreds or even thousands of
separate, sequentially activated instances, that are linked together to make higher voltages, and to put those higher voltages near other areas of 9600 DPI printed material, like bacteria at gel, membrane transport chemicals (proteins, peptides,
chemicals), possibly even single or double stranded DNA or RNA viruses, or even capsid viruses to cause 7 times higher migration through and permeability at tissue; I read online that electroporation with DMSO after that caused 8 times greater
transfection, so DMSO at the paper circle with the elecroporation could have another 8 times multiplier; Another thing that could heighten gene therapy transmissivity at a 3 mm paper circle: The bacteria as well as single or double stranded DNA or RNA
viruses with the CRISPR/cas9 could be engineered to be immunotransparent (immunoneutral surface), with the body’s first immune response at 20-40 days from first appearing at the circulatory system;
Notably, it could be possible to do a bacterial gene therapy, or all synthesized gene gene therapy with just sequenced, or mass produced at organisms, but outside of organism nucleotide chemicals, micro sugar probe inoculators, 9600 DPI printed
electroporation paper circuits on a 3 mm circle, DMSO (or a more optimal chemical), flavor and color user preferrable enzyme actions on chemicals that determine the actual gene therapy installed, also the membrane transport proteins, peptides, or
chemicals linked to the actual CRISPR/cas9 genes to bring the gene therapy to the cytes, also, it is possible that nuclear envelope transport/focus peptides I read about could be placed at CRISPR/cas9 assemblages to cause a power of two or even orders of
magnitude greater genetic insertion, successful translation, transcription, and propagation from nuclear transport; One reference says 70% electroporation transfection efficiency when also treated with DMSO,
https://www.cell.com/molecular-therapy-family/
molecular-therapy/pdf/S1525-0016%2816%2936452-8.pdf
If it is possible to inkjet print, at manufacturing quantities, a 7 to 14 layer of ink/electricity source/reagent/bacteria (or other CRISPR/cas9 source) at a 8.5 times 11 piece of paper for $11, then 71.9 3 mm circles times 93.1 circles is 6696 3 mm
gene therapy flavor and color user experience voluntary gene therapy dose applications; notably this is 608 apllications per $1, or .164 cents per dose, or about 6 doses per cent.
It is also possible soaking the paper in 3 of the ingredients, and just printing the electroporation circuits, biochemicals, DMSO (or more effective duoalkane sulphoxide), actual gene sequences, bacteria, single or doube stranded DNA or RNA viruses, the
polymer layer that causes deliquescent (autogooey) liquid layer to be at the dermis side, and the immunocolorizing material that lets people know when the gene therapy is successful;
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