Do vitamin D supplements offer kidney-related benefits for individuals
with high diabetes risk?
Trial shows no significant effects on kidney outcomes

Date:
August 6, 2021
Source:
American Society of Nephrology
Summary:
In a clinical trial of individuals at high risk for developing
type 2 diabetes, which is the leading cause of kidney disease,
vitamin D supplementation did not have significant effects on
kidney health. As participants were not selected according to
baseline vitamin D levels, investigators cannot exclude a kidney
benefit for individuals with vitamin D deficiency.



FULL STORY ==========================================================================
A recent clinical trial described in CJASN has examined the potential of vitamin D supplementation for protecting the kidney health of individuals
with pre-diabetes.


==========================================================================
In the general population, low blood vitamin D levels have been associated
with higher risks of various diseases, including type 2 diabetes and
kidney disease.

Sun H. Kim, MD, MS (Stanford University School of Medicine) and her
colleagues conducted a secondary analysis of the Vitamin D and type 2
diabetes (D2d) study to evaluate the effects of vitamin D supplementation
on kidney health in individuals with pre-diabetes, a condition that
increases risk for type 2 diabetes, which in turn is the leading cause
of kidney disease.

The study randomized 2,423 adults with overweight/obesity and pre-diabetes
to vitamin D3 4000 IU per day or placebo, for a median treatment duration
of 2.9 years. "The D2d study is unique because we recruited individuals
with high-risk pre-diabetes, having 2-out-of-3 abnormal glucose values,
and we recruited more than 2,000 participants, representing the largest
vitamin D diabetes prevention trial to date," said Dr. Kim.

During the trial, there were 28 cases of kidney function worsening in
the vitamin D group and 30 in the placebo group, and the average change
in kidney function during follow-up was similar in both groups. "Our
results did not show a benefit of vitamin D supplements on kidney
function. About 43% of the study population was taking outside-of-study
vitamin D, up to 1000 IU daily, at study entry, though. Among those who
were not taking any vitamin D on their own, there was a suggestion for
vitamin D lowering the amount of urine protein over time, which means
that it could have a beneficial effect on kidney health.

Additional studies are needed to look into this further." Dr. Kim
added that vitamin D supplementation is popular, and it's difficult
for clinical trials of vitamin D supplementation to show a benefit if
the population studied is not vitamin D deficient. "The majority of
the study population had sufficient blood vitamin D levels and normal
kidney function," she said. "Benefits of vitamin D might be greater in
people with low blood vitamin D levels and/or reduced kidney function."
Study co-authors include Irwin G. Brodsky, MD, Ranee Chatterjee, MD,
MPH, Sangeeta R. Kashyap, MD, William C. Knowler, MD, DrPH, Emilia Liao,
MD, Jason Nelson, MPH, Richard Pratley, MD, Neda Rasouli, MD, Ellen
M. Vickery, MS, Mark Sarnak, MD, MS, and Anastassios G. Pittas, MD, MS.

Disclosures: The authors reported no relevant financial disclosures
associated with this publication.

========================================================================== Story Source: Materials provided by American_Society_of_Nephrology. Note: Content may be edited for style and length.


========================================================================== Journal Reference:
1. Sun H. Kim, Irwin G. Brodsky, Ranee Chatterjee, Sangeeta R. Kashyap,
William C. Knowler, Emilia Liao, Jason Nelson, Richard Pratley,
Neda Rasouli, Ellen M. Vickery, Mark Sarnak, Anastassios
G. Pittas. Effect of Vitamin D Supplementation on Kidney Function
in Adults with Prediabetes.

Clinical Journal of the American Society of Nephrology, 2021; 16
(8): 1201 DOI: 10.2215/CJN.00420121 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2021/08/210806171913.htm

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