MRI reveals altered brain structure in fetuses exposed to alcohol

Date:
December 1, 2021
Source:
Radiological Society of North America
Summary:
In the first MRI-based study to investigate pre-natal alcohol
exposure, researchers found significant changes in the brain
structure of fetuses exposed to alcohol compared to healthy
controls.



FULL STORY ==========================================================================
In the first MRI-based study to investigate pre-natal alcohol exposure, researchers found significant changes in the brain structure of fetuses
exposed to alcohol compared to healthy controls. Results of the study
are being presented today at the annual meeting of the Radiological
Society of North America (RSNA).


========================================================================== "Fetal alcohol syndrome is a worldwide problem in countries where alcohol
is freely available," said Gregor Kasprian, M.D., associate professor of radiology at the Medical University of Vienna in Austria. "It's estimated
that 9.8% of all pregnant women are consuming alcohol during pregnancy,
and that number is likely underestimated." Fetal alcohol syndrome is the
most severe form of a group of conditions called fetal alcohol spectrum disorders that result from alcohol exposure during pregnancy. Babies
born with fetal alcohol spectrum disorders may have specific physical
features, learning disabilities, behavioral problems or speech and
language delays. According to Dr. Kasprian, one in 70 pregnancies with
alcohol exposure results in fetal alcohol syndrome.

"There are many postnatal studies on infants exposed to alcohol,"
Dr. Kasprian said. "We wanted to see how early it's possible to find
changes in the fetal brain as a result of alcohol exposure." For the
study, researchers recruited 500 pregnant women who were referred for
a fetal MRI for clinical reasons. On an anonymous questionnaire, 51of
the women admitted to consuming alcohol during their pregnancy. The questionnaires used were the Pregnancy Risk Assessment Monitoring System (PRAMS), a surveillance project of the Centers for Disease Control
and Prevention and health departments, and the T-ACE Screening Tool,
a measurement tool of four questions that identify risk drinking.

"We provided a safe environment where women could feel comfortable
honestly answering the questions," Dr. Kasprian said.



========================================================================== After eliminating some of the fetal MRIs for reasons such as structural
brain anomalies and/or poor image quality, the final study group consisted
of 26 fetal MRI exams from 24 alcohol-positive fetuses and a control group
of 52 gender- and age-matched healthy fetuses. At the time of imaging,
fetuses ranged in age between 20 and 37 weeks.

The researchers used super-resolution imaging, which allowed them to
create one dataset to re-construct each fetal brain. Next, they completed
an analysis of 12 different brain structures, computing total brain
volume and segment volumes of specific brain compartments.

"One of the main hallmarks of our study is that we investigated so many
smaller sub-compartments of the brain," said co-author Marlene Stuempflen, M.D., scientific researcher at the Medical University of Vienna.

The statistical analysis revealed two major differences in the
alcohol-exposed fetuses compared to healthy controls: an increased volume
in the corpus collosum and a decreased volume in the periventricular zone.

"This is the first time that a prenatal imaging study has been able to
quantify these early alcohol-associated changes," Dr. Stuempflen said.



==========================================================================
The corpus collosum is the main connection between the brain's two
hemispheres.

Dr. Stuempflen noted that it is fitting that this very central structure
is affected, because the clinical symptoms of fetal alcohol spectrum
disorders are highly heterogenous, or diverse, and cannot be pinpointed
to one specific substructure of the brain.

"The changes found in the periventricular zone, where all neurons are
born, also reflect a global effect on brain development and function,"
she said.

The researchers said finding a thicker corpus collosum in the
alcohol-positive fetuses was surprising because the corpus collosum is
thinner in infants with fetal alcohol spectrum disorders.

"It appears that alcohol exposure during pregnancy puts the brain on a
path of development that diverges from a normal trajectory," Dr. Kasprian
said. "Fetal MRI is a very powerful tool to characterize brain development
not only in genetic conditions, but also acquired conditions that result
from exposure to toxic agents." Additional co-authors are Ernst Schwartz, M.Sc., Mariana Diogo, M.D., Ph.D., Sarah Glatter, M.D., M.M.Sc., Birgit Pfeiler, Victor Schmidbauer, M.D., Lisa Bartha-Doering, Ph.D., Rainer
Seidl, M.D., Elisabeth Krampl-Bettelheim, M.D., and Daniela Prayer, M.D.

========================================================================== Story Source: Materials provided by
Radiological_Society_of_North_America. Note: Content may be edited for
style and length.


==========================================================================


Link to news story: https://www.sciencedaily.com/releases/2021/12/211201085144.htm

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