• Ibrutinib improves survival for younger

    From ScienceDaily@1:317/3 to All on Thu Nov 4 21:30:34 2021
    Ibrutinib improves survival for younger people with diffuse large B-cell lymphoma

    Date:
    November 4, 2021
    Source:
    NIH/National Cancer Institute
    Summary:
    New evidence suggests that adding the targeted therapy ibrutinib
    (Imbruvica) to a standard chemotherapy regimen can improve how
    long some younger people with a specific form of diffuse large
    B-cell lymphoma (DLBCL) live.



    FULL STORY ==========================================================================
    New evidence suggests that adding the targeted therapy ibrutinib
    (Imbruvica) to a standard chemotherapy regimen can improve how long some younger people with a specific form of diffuse large B-cell lymphoma
    (DLBCL) live. The findings, published November 4, 2021, in Cancer Cell,
    come from a new analysis by researchers at the National Cancer Institute
    (NCI), part of the National Institutes of Health, of a previously
    conducted phase 3 clinical trial.


    ========================================================================== Initial results from that study, known as the PHOENIX trial, showed that combining ibrutinib with the standard chemotherapy regimen did not help patients with a form of DLBCL called non-GCB DLBCL to live longer overall.

    However, by analyzing tumor biopsy samples from patients on the trial,
    NCI researchers and their collaborators have now shown that younger
    patients with specific genetic subtypes of non-GCB DLBCL, called MCD
    and N1, had an exceptional response to the treatment combination, with
    all such patients alive without disease three years after diagnosis.

    "People thought the trial didn't work," said Louis M. Staudt, M.D.,
    Ph.D., chief of the Lymphoid Malignancies Branch in the Cancer for
    Cancer Research at NCI. "But there was something interesting going on --
    if you just considered younger patients under the age of 60, they had
    a real benefit from ibrutinib, and we now understand why." "This new
    analysis provides a compelling rationale for doctors to consider adding ibrutinib to standard chemotherapy for the initial treatment of younger patients with non-GCB DLBCL," said Wyndham H. Wilson, M.D., Ph.D.,
    senior investigator in the Lymphoid Malignancies Branch and a co-author
    of the study.

    DLBCL is the most common type of lymphoma, accounting for 40% of lymphoma
    cases worldwide. This fast-growing cancer affects B cells, a type of
    white blood cell, and usually starts in the lymph nodes. People with
    DLBCL are typically treated with a chemotherapy regimen known as R-CHOP
    that includes cyclophosphamide, doxorubicin, vincristine, prednisone,
    and the monoclonal antibody rituximab. But R-CHOP is not effective for
    all people with DLBCL.

    In the 2000s, to better understand individual variation in treatment
    response, researchers analyzed the patterns of gene activity in DLBCL
    tumors. They discovered that there are three molecular subgroups of
    DLBCL: germinal center B cell-like (GCB), activated B cell-like (ABC),
    and unclassified. Researchers later found that these subgroups respond differently to chemotherapy. More recently, researchers showed that the
    ABC and GCB subgroups can be further divided into seven genetic subtypes
    that also respond differently to chemotherapy.



    ========================================================================== Ibrutinib was the first targeted therapy to be evaluated for the treatment
    of DLBCL. The drug works by blocking the activity of Bruton tyrosine
    kinase, a protein that is involved in the growth and survival of B
    cells. Cancer cells of ABC DLBCL require this protein to survive. In a
    previous phase 2 clinical trial involving patients with relapsed DLBCL, researchers found that treatment with ibrutinib alone resulted in tumor shrinkage in 37% of patients with the ABC type but only 5% of those with
    the GCB type.

    Subsequently, researchers launched the PHOENIX trial to evaluate the
    impact of adding ibrutinib to R-CHOP in patients with newly diagnosed
    non-GCB DLBCL.

    Although that trial showed no survival benefit of adding ibrutinib
    to R-CHOP overall, when the researchers looked specifically at trial participants aged 60 and younger, the benefits of adding ibrutinib to
    R-CHOP became evident.

    Patients older than age 60 did not benefit from the addition of
    ibrutinib to R- CHOP, likely because they frequently did not tolerate
    this combination well and had to stop treatment early.

    What was unclear from the PHOENIX trial was whether all younger patients
    with non-GCB DLBCL benefited from ibrutinib, or if there was greater
    benefit for patients with certain genetic subtypes. To gain insights
    into this question, researchers performed genetic analyses on tumor
    samples from 773 of the 838 participants and determined their subtypes
    using an algorithm called LymphGen that Dr. Staudt developed with his
    NCI colleague George Wright, Ph.D.

    They showed that most of the benefit from ibrutinib was in patients
    with ABC DLBCL, mirroring the previous study. ABC DLBCL can be divided
    into four genetic subtypes: MCD, N1, BN2, and A53. The researchers found
    that patients who were 60 and younger with the MCD subtype had three-year event-free and overall survival rates of 100% with ibrutinib and R-CHOP, compared with three-year event-free survival of 48% and three-year overall survival of 69.6% with R-CHOP alone. Younger patients with the N1 subtype
    also had three-year event-free and overall survival rates of 100% with ibrutinib and R-CHOP, compared with three- year event-free and overall
    survival of 50% with R-CHOP alone.

    Younger patients with the BN2 genetic subtype did not appear to benefit
    from the addition of ibrutinib. However, that subtype already had an 82% overall survival rate with R-CHOP alone.

    In addition to the exceptional response rate in MCD and N1 DLBCL,
    ibrutinib did provide benefit for some other younger patients with
    non-GCB DLBCL. More research is needed to determine whether the A53
    subtype -- which the researchers could not identify in this study because
    of technical reasons - - falls into this category.

    Although no tests are commercially available to identify the MCD and
    N1 subtypes, Dr. Staudt pointed out that the identification of non-GCB
    DLBCL is done routinely.

    "For years we have only had chemotherapy and rituximab to offer these patients," he said. "Now, we hope that adding ibrutinib to current
    therapy may give younger patients a better chance of surviving this
    aggressive cancer." This study was supported by the Intramural Research Programs of NIH and NCI.

    Janssen Research and Development, LLC, sponsored the PHOENIX trial.

    ========================================================================== Story Source: Materials provided by NIH/National_Cancer_Institute. Note: Content may be edited for style and length.


    ========================================================================== Journal Reference:
    1. Wyndham H. Wilson, George W. Wright, Da Wei Huang, Brendan
    Hodkinson,
    Sriram Balasubramanian, Yue Fan, Jessica Vermeulen, Martin
    Shreeve, Louis M. Staudt. Effect of ibrutinib with R-CHOP
    chemotherapy in genetic subtypes of DLBCL. Cancer Cell, 2021;
    DOI: 10.1016/j.ccell.2021.10.006 ==========================================================================

    Link to news story: https://www.sciencedaily.com/releases/2021/11/211104115344.htm

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