Inflammatory cytokine levels may predict outcomes in orthopedic trauma patients
Date:
November 3, 2021
Source:
Wiley
Summary:
Inflammatory cytokines are molecules that are secreted by immune
cells to promote inflammation. A study found that measuring
inflammatory cytokines may help predict patient outcomes after
traumatic injury, which is the leading cause of mortality in
individuals under 50 years of age.
FULL STORY ========================================================================== Inflammatory cytokines are molecules that are secreted by immune cells
to promote inflammation. A study published in the Journal of Orthopaedic Research found that measuring inflammatory cytokines may help predict
patient outcomes after traumatic injury, which is the leading cause of mortality in individuals under 50 years of age.
==========================================================================
In the study of 58 patients with an average age of 40 years who
experienced severe bone, joint, and muscle trauma, six patients (10%)
suffered pulmonary complications and five (9%) had acute kidney injury.
Adding the cytokine interleukin-6 to predictive models of patient
outcomes (such as what's called the New Injury Severity Score, or NISS) significantly improved predictions of pulmonary complications, the need
for intensive care, and the length of hospital stay. Adding the cytokine interleukin- 8 significantly improved predictions of acute kidney injury.
"This is the first time we have combined parameters of external anatomic
injury (NISS) with parameters of the internal physiologic response to
injury (cytokines) to determine trauma patient outcomes," said lead
author Arun Aneja, MD, PhD, of the University of Kentucky.
========================================================================== Story Source: Materials provided by Wiley. Note: Content may be edited
for style and length.
========================================================================== Journal Reference:
1. Arun Aneja, David C. Landy, Peter N. Mittwede, Ashley Y. Albano,
Robert
J. Teasdall, Alexander Isla, Matthew Kavolus. Inflammatory
cytokines associated with outcomes in orthopedic trauma patients
independent of New Injury Severity score: A pilot prospective cohort
study. Journal of Orthopaedic Research, 2021; DOI: 10.1002/jor.25183 ==========================================================================
Link to news story:
https://www.sciencedaily.com/releases/2021/11/211103082557.htm
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