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here were 106,699 drug-involved overdose deaths reported in the U.S. in
2021 (Figure 1); 69% of cases occurred among males (yellow line).
Synthetic opioids other than methadone (primarily fentanyl) were the main driver of drug overdose deaths with a nearly 7.5-fold increase from 2015
to 2021 (Figure 2).
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https://nida.nih.gov/research-topics/trends-statistics/overdose-death- rates#:~:text=There%20were%20106%2C699%20drug%2Dinvolved,to%202021%20(Figu re%202).>
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