What is Mounjaro?

Mounjaro is a once-weekly injection that is FDA approved to be used to decrease blood sugar (blood glucose) in adults who have type 2 diabetes. It should be used together with diet and exercise. Mounjaro has also been shown in clinical trials to be
useful for weight loss, however it is currently not an FDA approved weight loss drug.

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Diabetes is a long term condition when your blood sugars (HbA1c) become too high because the body does not produce or use insulin normally. Overtime high blood sugars can cause serious health problems including heart disease, vision loss and kidney
disease.

Mounjaro works to reduce blood sugar levels by increasing your insulin production and also lowering the amount of sugar your liver makes. It also slows the rate food passes through your body which makes you feel full longer.

Mounjaro (Tirzepatide) is the first dual GIP/GLP-1 receptor agonist which means it works on the glucose-dependent insulinotropic polypeptide (GIP) receptors and the glucagon-like peptide-1 (GLP-1) receptors.

Mounjaro can be used as a single therapy or with other diabetes medicines including metformin, sulfonylureas or SGLT2 inhibitors.

It is not known if this medicine can be used in people who have had pancreatitis.

Mounjaro is not for use in people with type 1 diabetes

Is Mounjaro used for weight loss?
Mounjaro has also shown to help lose weight in overweight patients. It is currently in Phase 3 clinical trials for weight loss in adults who are overweight, obese or have weight related health issues. Mounjaro has received FDA Fast Track designation to
speed up its path for FDA submission for treating adults with obesity, or overweight with weight-related health conditions.
In the SURMOUNT-1 clinical trial the average weight loss after 72 weeks was 15% for the 5mg dose, 19.5% for the 10mg dose and 20.9% for the 15mg dose.
Mounjaro is not FDA approved as a weight loss medication.
Important information

Mounjaro may cause thyroid C-cell tumors. Tell your doctor if you have a personal or family history of thyroid cancer or a condition called Multiple Endocrine Neoplasia (MEN) syndrome (a syndrome that causes tumors to develop on endocrine glands). If you
experience any of the following symptoms, call your doctor immediately: lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath.

Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests to check your body’s response to this medicine.

Before using Mounjaro
Tell your doctor and pharmacist if you are allergic to Mounjaro, any other medications, or any of the ingredients in this injection. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
Tell your doctor if you have or have ever had pancreas or kidney disease, stomach problems such as difficulty digesting food, or history of diabetic retinopathy.
Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking this medicine, call your doctor.
How should I use Mounjaro?

Mounjaro comes as a solution (liquid) in a pre-filled pen to be injected subcutaneously (under the skin). It is usually given once a week with or without meals at any time of day. Follow the directions on your prescription label carefully, and ask your
doctor or pharmacist to explain any part you do not understand. Use this medicine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose and gradually increase your dose, not more than once every 4 weeks.

You may change the day of the week you inject this medicine as long as at least 3 days have passed between doses.

You may administer insulin in the same area as Mounjaro but they should not be given right next to each other. Also, you should not mix Mounjaro and insulin in the same injection.

Mounjaro controls type 2 diabetes but does not cure it. It may take 4 weeks or longer before you feel the full benefit of this medicine. Continue to take this medicine even if you feel well. Do not stop taking this medicine without talking to your doctor.

Mounjaro can be injected in the abdomen, thigh or upper arm. Rotate injection sites with each dose.

What should I do if I miss a dose?

Take the missed dose as soon as you remember it within 4 days after the missed dose. However, if more than 4 days have passed, skip the missed dose and continue your regular dosing schedule. Do not inject two doses within 3 days of each other.

What should I do in case of overdose?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at Poison Help If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at
911.

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