PH darah normal konon berkisar 7
..Air PDAM/PAM kalau tidak salah harus ber-PH kurang lebih 7 juga.
Air minum dalam kemasan yang beredar secara nasional, pun menurut ketentuan pemerintah- harus sekitar 7juga.
Kurang tidur dan stress konon akan meurunkan PH darah dalam tubuh.
PH tubuh dibawah 7 tanda kondisi tubuh yang kurang sehat. Tetapi PH darah di atas 7 bukan tanda penyakit.
Makan makanan ber PH tinggi tidak apa-apa. Buah-buahan seperti mangga dan pepaya memiliki PH 9. Sementara buah semangka dan mentimun memiliki PH 10.
PH 11,5 ke atas kalau tidak salah akan mulai menguraikan lemak/minyak, termasuk lapisan glikoprotein "kulit" virus. Sabun ber-PH 12.
Penelitian di Amerika Serikat menunjukkan bahwa pada suhu 37 derajat celcius, koronavirus stabil pada PH 6, dan akan mulai "inefektif" dan mengalami deaktivasi pada PH 8.
Jadi besar kemungkan bahwa pada PH 8 ke atas koronavirus akan "mati".
PH darah bisa ditingkatkan/diturunkan lewat makanan/minuman yang masuk ke badan.
Hasil penelitian di Amerika Serikat ada di bawah ini: https://pubmed.ncbi.nlm.nih.gov/2159562/
Conformational Change of the Coronavirus Peplomer Glycoprotein at pH
8.0 and 37 Degrees C Correlates With Virus Aggregation and Virus-Induced
Cell Fusion
L S Sturman
1
, C S Ricard, K V Holmes
Affiliations
- PMID: 2159562
- PMCID: PMC249489
Abstract
We have obtained biochemical and electron microscopic evidence of conformational changes at pH 8.0 and 37 degrees C in the coronavirus
spike glycoprotein E2 (S). The importance of these changes is reflected
in the loss of virus infectivity, the aggregation of virions, and
increased virus-induced cell fusion at the same pH. Coronavirus
(MHV-A59) infectivity is exquisitely sensitive to pH. The virus was
quite stable at pH 6.0 and 37 degrees C (half-life, approximately 24 h)
but was rapidly and irreversibly inactivated by brief treatment at pH
8.0 and 37 degrees C (half-life, approximately 30 min). Virions treated
at pH 8.0 and 37 degrees C formed clumps and large aggregates. With
virions treated at pH 8.0 and 37 degrees C, the amino-terminal peptide
E2N (or S1) was released from virions and the remaining peptide, E2C
(S2), was aggregated. Viral spikes isolated from detergent-treated
virions also aggregated at pH 8.0 and 37 degrees C. Loss of virus
infectivity and E2 (S) aggregation at pH 8.0 and 37 degrees C were
markedly enhanced in the presence of dithiothreitol. On the basis of the effects of dithiothreitol on the reactions of the peplomer, we propose
that release of E2N (S1) and aggregation of E2C (S2) may be triggered by rearrangement of intramolecular disulfide bonds. The aggregation of
virions and the isolated E2 (S) glycoprotein at pH 8.0 and 37 degrees C
or following treatment with guanidine and urea at pH 6.0 and 37 degrees C indicate that an irreversible conformational change has been induced in
the peplomer glycoprotein by these conditions. It is interesting that coronavirus-induced cell fusion also occurred under mildly alkaline conditions and at 37 degrees C. Some enveloped viruses, including
influenza viruses and alphaviruses, show conformational changes of spike glycoproteins at a low pH, which correlates with fusion and penetration
of those viruses in acidified endocytic vesicles. For coronavirus
MHV-A59, comparable conformational change of the spike glycoprotein E2
(S) and cell fusion occurred at a mildly alkaline condition, suggesting
that coronavirus infection-penetration, like that of paramyxoviruses and lentiviruses, may occur at the plasma membrane, rather than within
endocytic vesicles.
On 4 Apr 2020 at 09.13.44 GMT+2, "pulaha9@gmail.com" <pulaha9@gmail.com> wrote:
PH darah normal konon berkisar 7
Tepatnya PH darah normal ada di sekitar 7.35 sampai 7.45 dan apa bila kurang dari itu akan jatuh ke kondisi yang disebut acidosis dan apabila lebih dari pada itu akan jadi alkalosis.
..Air PDAM/PAM kalau tidak salah harus ber-PH kurang lebih 7 juga.
Air minum dalam kemasan yang beredar secara nasional, pun menurut ketentuan pemerintah- harus sekitar 7juga.
Kurang tidur dan stress konon akan meurunkan PH darah dalam tubuh.
PH tubuh dibawah 7 tanda kondisi tubuh yang kurang sehat. Tetapi PH darah di
atas 7 bukan tanda penyakit.
Tidak, apabila masuk dibawah 7, akan acidosis metabolic dan akibatnya, orang akan mengap mengap alias hypercapnia , karena tubuh berusaha menaikan kembali ke PH normal.
Tubuh mempunyai sistem yang di sebut metabolic dan respiratoric untuk mengenai
keseimbangan asam basa dalam tubuh, sehingga apabila terjadi gangguan asam basa, system ini akan jalan.
Tubuh akan selalu berusaha menjaga keseimbangan asam basa ini, apapun yang terjadi. Baik tubuh berhasil mengkompesasi, maupun tidak berhasil mengkompensasi.
Untuk baca lebih lanjut, om bisa google mengenai difference between respiratory and metabolic acidosis and alkalosis akan banyak site yang menjelaskan apa perbedaannya, dan apa yang akan terjadi, pada pernafasan apabila terjadi metabolic acidosis atau alkalosis.
Makan makanan ber PH tinggi tidak apa-apa. Buah-buahan seperti mangga dan pepaya memiliki PH 9. Sementara buah semangka dan mentimun memiliki PH 10.
PH 11,5 ke atas kalau tidak salah akan mulai menguraikan lemak/minyak, termasuk lapisan glikoprotein "kulit" virus. Sabun ber-PH 12.
Penelitian di Amerika Serikat menunjukkan bahwa pada suhu 37 derajat celcius,
koronavirus stabil pada PH 6, dan akan mulai "inefektif" dan mengalami deaktivasi pada PH 8.
Jadi besar kemungkan bahwa pada PH 8 ke atas koronavirus akan "mati".
PH darah bisa ditingkatkan/diturunkan lewat makanan/minuman yang masuk ke badan.
Apabila PH darah lebih dari 7.6, sudah masuk ke dalam kondisi alkalosis berat,
dialysis sudah merupakan opsi untuk mengatasi alkalosis ini, apalagi PH 8.
Pada saat alkalosis berat, bisa membuat orang seperti dilerium, kejang sampai koma.
Hasil penelitian di Amerika Serikat ada di bawah ini: https://pubmed.ncbi.nlm.nih.gov/2159562/
Conformational Change of the Coronavirus Peplomer Glycoprotein at pH
8.0 and 37 Degrees C Correlates With Virus Aggregation and Virus-Induced Cell Fusion
L S Sturman
1
, C S Ricard, K V Holmes
Affiliations
- PMID: 2159562
- PMCID: PMC249489
Abstract
We have obtained biochemical and electron microscopic evidence of conformational changes at pH 8.0 and 37 degrees C in the coronavirus
spike glycoprotein E2 (S). The importance of these changes is reflected
in the loss of virus infectivity, the aggregation of virions, and
increased virus-induced cell fusion at the same pH. Coronavirus
(MHV-A59) infectivity is exquisitely sensitive to pH. The virus was
quite stable at pH 6.0 and 37 degrees C (half-life, approximately 24 h)
but was rapidly and irreversibly inactivated by brief treatment at pH
8.0 and 37 degrees C (half-life, approximately 30 min). Virions treated
at pH 8.0 and 37 degrees C formed clumps and large aggregates. With
virions treated at pH 8.0 and 37 degrees C, the amino-terminal peptide
E2N (or S1) was released from virions and the remaining peptide, E2C
(S2), was aggregated. Viral spikes isolated from detergent-treated
virions also aggregated at pH 8.0 and 37 degrees C. Loss of virus infectivity and E2 (S) aggregation at pH 8.0 and 37 degrees C were
markedly enhanced in the presence of dithiothreitol. On the basis of the effects of dithiothreitol on the reactions of the peplomer, we propose
that release of E2N (S1) and aggregation of E2C (S2) may be triggered by rearrangement of intramolecular disulfide bonds. The aggregation of
virions and the isolated E2 (S) glycoprotein at pH 8.0 and 37 degrees C
or following treatment with guanidine and urea at pH 6.0 and 37 degrees C indicate that an irreversible conformational change has been induced in
the peplomer glycoprotein by these conditions. It is interesting that coronavirus-induced cell fusion also occurred under mildly alkaline conditions and at 37 degrees C. Some enveloped viruses, including
influenza viruses and alphaviruses, show conformational changes of spike glycoproteins at a low pH, which correlates with fusion and penetration
of those viruses in acidified endocytic vesicles. For coronavirus
MHV-A59, comparable conformational change of the spike glycoprotein E2
(S) and cell fusion occurred at a mildly alkaline condition, suggesting that coronavirus infection-penetration, like that of paramyxoviruses and lentiviruses, may occur at the plasma membrane, rather than within endocytic vesicles.
Ini jurnal lama, namun masih bisa di cite, tapi ini tidak membicarakan di dalam tubuh manusia. ini lebih membicarakan virus nya sendiri.
Karena dalam tubuh manusia, PH darah normal itu adalah 7.35 sampai 7.45 karena
kalau tidak di antara itu, system dalam tubuh akan berkerja untuk menjaga di dalam jarak tersebut.
Apabila ingin mencari bagaimana cara disinfectan bisa baca baca site ini
<https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/disinfecting-your-home.html>
Disana disebutkan, bisa mengunakan bleach atau bahasa Indonesianya kaporit, gunakan 5 sendok makan kaporit yang kemudian di larutkan dalam 1 galon air.
1 us gallon = 3,785411784 litre
Itu bisa digunakan sebagai disinfectan.
Mudah mudahan bisa berguna, dan tetap jaga diri dan keluarga.
Salam
--
- alien -
~ Work like you don't the money ~
~ Love like you've never been hurt ~
~ Dance like nobody is looking ~
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