• Chronic pelvic pain & symptoms of CFS, IBS and Fibromyalgia

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    Chronic pelvic pain & symptoms of CFS, IBS and Fibromyalgia

    sci.med.prostate.prostatitis

    Many men with chronic pelvic pain report symptoms of CFS, IBS and Fibromyalgia

    (too old to reply)
    ⊙_⊙ 3 months ago
    PermalinkRaw Message Many men with chronic pelvic pain report symptoms of CFS, IBS and Fibromyalgia. Is there a connection?

    Note: CFS = Chronic Fatigue Syndrome, IBS = Irritable Bowel Syndrome, Fibro = Fibromyalgia.

    Many Patients have reported a CFS-like illness at or near the onset of their CP/CPPS. Recent studies have shown that CFS is indeed linked to chronic prostatitis. In general, studies have found that there is an association between urologic chronic pelvic
    pain syndromes (CPPS and IC) with conditions like chronic fatigue, fibromyalgia, irritable bowel syndrome, multiple chemical sensitivities, and temporomandibular disorder.


    Chronic Fatigue Syndrome

    Chronic Fatigue Syndrome (CFS), also sometimes called myalgic encephalomyelitis (ME) in Europe, is defined as unexplained chronic fatigue that lasts for more than six months, impairs normal activities and has no identifiable medical or psychological
    problems to account for it.

    Four or more of the following symptoms must have been present for longer than six months:

    short-term memory loss or a severe inability to concentrate that affects work, school, or other normal activities
    sore throat
    swollen lymph nodes (eg. in the neck or armpits)
    muscle pain
    pain without redness or swelling in a number of joints
    intense or changing patterns of headaches
    unrefreshing sleep
    after any exertion, weariness that lasts for more than a day
    The fatigue must be severe: sleep or rest does not relieve it; the fatigue is not the result of excessive work or exercise; the fatigue substantially impairs a person’s ability to function normally at home, at work, and in social occasions. Even mild
    exercise often makes the symptoms, especially fatigue, much worse.

    Irritable Bowel Syndrome

    Symptoms of irritable bowel syndrome (IBS) include abdominal pain, mucus in the stools, and alternating diarrhoea and constipation. Other terms for irritable bowel syndrome include ‘spastic colon’ and ‘irritable colon’. Some of the more common
    signs of irritable bowel syndrome include:

    Abdominal pain or cramping that is often relieved by passing wind or faeces Alternating diarrhoea and constipation
    A sensation that the bowels are not fully emptied after passing a motion Abdominal bloating
    Mucus present in the stools
    Nausea
    Irritable bowel syndrome can be subdivided into three major categories:

    Constipation-predominant – the person tends to alternate constipation with normal stools. Symptoms of abdominal cramping or aching are commonly triggered by eating.
    Diarrhoea-predominant – the person tends to experience diarrhoea first thing in the morning or after eating. The need to go to the toilet is typically urgent and cannot be delayed. Incontinence may be a problem.
    Alternating constipation and diarrhoea.
    Note: recent studies have shown a link between IBS and certain sugars, and it is possible to cure yourself of IBS following a special diet.

    Fibromyalgia

    Fibromyalgia is a condition in which people describe symptoms that include widespread pain and tenderness in the body, often accompanied by fatigue, cognitive disturbance and emotional distress. The most common symptoms are:

    increased sensitivity to pain due to a decreased pain threshold
    increased responsiveness to sensory stimuli such as heat, cold, light and numbness or tingling
    extreme fatigue (tiredness)
    problems with cognition (impacting on memory and concentration)
    problems with sleep
    Symptoms can be mild, moderate or severe. Symptoms may disappear for extended periods of time, perhaps even years. Some people with fibromyalgia have other symptoms, such as irritable bowel syndrome, irritable or overactive bladder, headaches, and
    swelling and numbness or tingling in the arms and legs. Living with ongoing pain and fatigue often leads to secondary problems such as anxiety and depression.

    Symptoms similar in CFS, temporomandibular disorder and fibromyalgia

    By Elda Hauschildt

    CHICAGO: There is now preliminary evidence that patients with chronic fatigue syndrome, fibromyalgia and temporomandibular disorder share the same key symptoms.

    These symptoms include generalized pain sensitivity, sleep and concentration difficulties, bowel complaints, and headache. Researchers also say it is apparent that seven other localized and systemic illnesses may occur at the same time as the three
    conditions.

    These include chronic tension-type headache, irritable bowel syndrome, bladder pain syndrome/interstitial cystitis (BPS/IC), post-concussive syndrome, multiple chemical sensitivities, chronic pelvic pain and chronic low back pain.

    Seattle researchers recruited 25 chronic fatigue patients, 22 fibromyalgia patients and 25 temporomandibular patients from hospital- based clinics. All of the patients were diagnosed by their physicians. The control group numbered 22 healthy subjects
    from a dermatology clinic.

    All participants completed a 138-item symptom checklist. They then underwent brief physical examinations.

    Most patients reported few past diagnoses of the 10 clinical conditions outside of their primary diagnosis. Patients diagnosed with each of the three main conditions were more likely than control subjects to meet lifetime symptom and diagnostic criteria
    for many of the other conditions.

    The most striking finding was that of lifetime rates of irritable bowel syndrome. Researchers found the syndrome in 92 per cent of chronic fatigue, 77 per cent of fibromyalgia, and 64 per cent of temporomandibular disorder patients.

    Archives of Internal Medicine, 2000; 160: 221-227


    http://www.chronicprostatitis.com/chronic-prostatitis-linked-to-cfs-ibs-and-fibro/
    ⊙_⊙ 3 months ago
    PermalinkRaw Message Science, Art, Beauty by Josiah Zayner, Ph.D.


    JUL
    5

    I transplanted someone else's microbiome in(on)to my body and it was so surreal - Results - Part III

    This is a case study of a 35 year old caucasian Male of European ancestry living in the United States, a maternal Haplogroup of H1e1a and a paternal haplogroup of I1*. NOD2 Genotype SNP(rs2066844) CC indicating decreased risk of Crohn’s disease. The
    subject presented with increased bowel movements(3+ times a day) Bristol type stool 5-7, mainly 6. Blood in stool more than 2 but less than 5 times a month. Experiences nausea, abdominal cramps and pain 2 or more days a week with no correlated inducers
    besides stress. Diet consists mainly of rice, vegetables and meat protein(chicken or pork). Eats out 1-2 times per week. Average kilocalories consumed per day ~2100. Height 5’9”(1.75 m) weight before experiment 167 lbs (76 kg). Exercises 1-2 days per
    week. Subject also presents with type II bipolar disorder and takes clonazepam as needed to help sleep. Subject has chronic sinusitis with no clear cause and has been tested for allergies and nasal polyps both coming back negative or inconclusive.
    Subject has been diagnosed with chronic prostatitis and was treated with ciprofloxacin and then bactrim in Dec. 2013(also last time antibiotics were taken) which did not relieve symptoms. Acute symptoms resolved to mild pain during urination.

    The subject attempted a full body microbial transplant from a healthy donor Male caucasian ~30 year of age using fresh stool samples, skin, mouth and nasal swabs. Bacterial swabs were taken from, skin, mouth, nose, poop and environment before and
    throughout the experiment using sterile swabs and stored in 150mM NaCl and 0.01% Tween.

    The subject self treated with 500 mg Tetracycline and 500 mg Ciprofloxacin, four doses over 2.5 days. Subject also performed a complete body scrub with soap and tetracycline, including a nasal rinse. The subject proceeded to stay in a precleaned hotel
    room using new untouched sheets. The subject did not touch another person during the course of the transplant without the use of nitrile gloves. The subject stayed in the hotel room for 3 days and 3 nights during which he ingest 3-6 grams of donor feces
    enclosed in gelatin pills. He coated himself with 20-50mL saline solution containing swabs from the donors skin. He also inoculated his mouth and nasal passages no less than 6 times with the donors swabs. Patient returned home and attempted to clean and
    sterilize ~700 sq ft (65 sq m) apartment and inoculate it with donor skin bacterial cultures.

    Within one week of the experiment the subject’s bowel movements were consistently reduced to 1 time per day. Stomach pains and cramps reduced almost completely within 2 weeks. Subjects weight reduce to an average of ~ 160 lbs(73 kg) 2 months after the
    experiment. Diet has remained very similar(rice, veg, meat) except subject notices more meat(no craving) and a newfound craving for sugary foods. Prostatitis resolved completely. Symptoms from post nasal drip seem reduced but uncertain, symptoms still
    flare up at least 2-5 times a month. Bipolar disorder not affected.

    A total of 77 samples were collected before, during and after experiment. DNA extraction, 16s amplicon library prep using 515f and 806r and Illumina MiSeq 151x151 sequencing was done by Argonne National Lab in Batavia Illinois. Of the 77 samples 73 had
    counts.


    Data Analysis
    QIIME 1.9.1 was used for data analysis

    Samples 65(storage buffer) and 66(storage buffer and sterile swab) were control samples and used to filter out contamination using standard QIIME workflow. Afterward sample #55 had below 1000 counts and so was removed from the rest of the study.

    Beta diversity was calculated for poop samples using a jacknifed subset of 5000 sequences. PCoA plots of weighted UniFrac are displayed below.
    poopPCoA.labeled.png



    Less than two weeks after the transplant the microbiota in the gut of the subject became more closely related to the donors gut microbiota than to the subjects gut microbiota before the experiment.








    Observing the different types of bacteria in the samples both on the Class and Family levels, the subjects gut had increased diversity before the transplant (#9 and #11) as compared to after the transplant (50, 51, 52, 53) and had more similar diversity
    to the donor’s samples (59, 60). Diversity was insinuated by the portion of a sample belonging to species other than those the top 10-15 samples, Shown by "Other".


    Posted 5th July by Josiah Zayner


    http://www.ifyoudontknownowyaknow.com/2016/07/i-transplanted-someone-elses-microbiome.html?m=1
    ⊙_⊙ 3 months ago
    PermalinkRaw Message Analysis of Gut Microbiome Reveals Significant Differences between Men with Chronic Prostatitis/Chronic Pelvic Pain Syndrome and Controls.


    Urol. 2016 Aug;196(2):435-41. doi: 10.1016/j.juro.2016.02.2959. Epub 2016 Feb 27.

    Analysis of Gut Microbiome Reveals Significant Differences between Men with Chronic Prostatitis/Chronic Pelvic Pain Syndrome and Controls.
    Shoskes DA1, Wang H2, Polackwich AS3, Tucky B3, Altemus J4, Eng C5.
    Author information
    Abstract
    PURPOSE:
    Chronic prostatitis/chronic pelvic pain syndrome is a common disorder with heterogeneous etiologies and clinical features. The gut microbiome is a metabolically active ecosystem linked to systemic conditions (gut-brain axis). We hypothesize that the gut
    microbiome will show alterations between patients with chronic pelvic pain syndrome and controls.
    MATERIALS AND METHODS:
    We identified patients with chronic pelvic pain syndrome and controls who were asymptomatic or only had urinary tract symptoms. After rectal examination the soiled glove tip was immersed in sterile saline and stored on ice. Symptom severity was measured
    with the NIH-Chronic Prostatitis Symptom Index and clinical phenotype with UPOINT. Total DNA was extracted from the pellet of samples. MiSeq sequencing of bacterial specific 16S rRNA capture was performed. Taxonomic and bioinformatic analyses were
    performed using principal coordinate analysis, QIIME and LEfSe algorithms. RESULTS:
    There were 25 patients and 25 controls with complete data. Mean age was similar (chronic pelvic pain syndrome 52.3 vs control 57.0 years, p=0.27). For patients with chronic pelvic pain syndrome median symptom duration was 48 months, mean Chronic
    Prostatitis Symptom Index was 26.0 and mean UPOINT domain was 3.6. Three-dimensional UniFrac principal coordinate analysis revealed tighter clustering of controls in a space distinct from the wider clustering of cases (p=0.001) with cases having
    decreased alpha diversity (p=0.001). Compared to controls, 3 taxa were overrepresented in cases and 12 were underrepresented, eg Prevotella.
    CONCLUSIONS:
    Patients with chronic pelvic pain syndrome have significantly less gut microbiome diversity which clusters differently from controls, and robustly lower counts of Prevotella, with separation sufficient to serve as a potential biomarker. The gut
    microbiome may serve as disease biomarker and potential therapeutic target in chronic pelvic pain syndrome.
    Copyright © 2016 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

    KEYWORDS:
    gastrointestinal microbiome; pelvic pain; prostatitis
    PMID: 26930255 DOI: 10.1016/j.juro.2016.02.2959
    [PubMed - in process]

    https://www.ncbi.nlm.nih.gov/pubmed/26930255

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