• The Urinary Microbiome Differs Significantly Between Patients With Chro

    From II@21:1/5 to All on Tue Jul 11 22:54:06 2017
    Urology. 2016 Jun;92:26-32. doi: 10.1016/j.urology.2016.02.043. Epub 2016 Mar 9.

    The Urinary Microbiome Differs Significantly Between Patients With Chronic Prostatitis/Chronic Pelvic Pain Syndrome and Controls as Well as Between Patients With Different Clinical Phenotypes.

    Shoskes DA1, Altemus J2, Polackwich AS3, Tucky B3, Wang H4, Eng C5.
    Author information
    Abstract
    OBJECTIVE:
    To study the urinary microbiome of patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) compared with controls.
    METHODS:
    We identified 25 patients with CP/CPPS and 25 men who were either asymptomatic or only had urinary symptoms. Midstream urine was collected. Symptom severity was measured with the National Institutes of Health Chronic Prostatitis Symptom Index and
    clinical phenotype with UPOINT. Total DNA was extracted from the urine pellet and bacterial-specific 16Sr-DNA-capture identified by MiSeq sequencing. Taxonomic and functional bioinformatic analyses used principal coordinate analysis (PCoA)/MacQIIME,
    LEfSe, and PiCRUSt algorithms.
    RESULTS:
    Patients and controls were similar ages (52.3 vs 57.0 years, P = .27). For patients, median duration was 48 months, mean Chronic Prostatitis Symptom Index was 26.0, and mean UPOINT domains was 3.6. Weighted 3D UniFrac PCoA revealed tighter clustering
    of controls distinct from the wider clustering of cases (P = .001; α-diversity P = .005). Seventeen clades were overrepresented in patients, for example, Clostridia, and 5 were underrepresented, eg, Bacilli, resulting in predicted perturbations
    in functional pathways. PiCRUSt inferred differentially regulated pathways between cases and controls that may be of relevance including sporulation, chemotaxis, and pyruvate metabolism. PCoA-derived microbiomic differences were noted for neurologic/
    systemic domains (P = .06), whereas LEfSe identified differences associated with each of the 6 clinical features.
    CONCLUSION:
    Urinary microbiomes from patients with CP/CPPS have significantly higher alpha(phylogenetic) diversity which cluster differently from controls, and higher counts of Clostridia compared with controls, resulting in predicted perturbations of functional
    pathways which could suggest metabolite-specific targeted treatment. Several measures of severity and clinical phenotype have significant microbiome differences.
    Copyright © 2016 Elsevier Inc. All rights reserved.
    PMID: 26970449 DOI: 10.1016/j.urology.2016.02.043

    https://www.ncbi.nlm.nih.gov/pubmed/26970449

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  • From Jake@21:1/5 to All on Sun Jun 14 20:43:43 2020
    Diet for prostatitis

    Diet should be one of the cornerstones of treatment for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Examining your diet is part of a whole-body approach to your health, especially since many causes of CP/CPPS and pelvic tension stem from
    problems that take place outside of the prostate. Certain foods and allergies to foods can create reactions in your body in the form of inflammation, and this can contribute to pelvic tension and pain. That is why looking at diet when diagnosing and
    treating CP/CPPS can help to eliminate inflammation.

    Diet for prostatitis is part of the NPAT treatment program for CP/CPPS. NPAT stands for:

    Natural treatments (ALCAT, elimination diets, and wheat-free diets) Phytotherapy (pollen and quercetin together with probiotics)
    Alternative Treatments (acupuncture, prostate massage, pelvic rehabilitation and therapy)
    Total body (exercise, chronic stress management, lifestyle)
    It is important for you to figure out and avoid foods that can exacerbate your symptoms. Common foods that have been found to exacerbate prostatitis symptoms include the following:

    Spicy foods
    Hot peppers
    Alcoholic beverages
    Acidic foods
    Wheat
    Gluten
    Caffeine
    Hot peppers derive their spiciness from capsaicin, which can increase rectal sensitivity in people with irritable bowel syndrome, a condition frequently found in men with CP/CPPS. Read more on Foods to Avoid.

    Bowel health and prostatitis seem to be connected. That is why eating foods containing probiotics or taking quality probiotic supplements is part of a healthy diet for prostatitis. Probiotics are the beneficial, or helpful, gut microflora and include
    bacteria that normally reside in balance with other bacteria in the intestinal tract.

    Other dietary causes of prostatitis could be related to a zinc deficiency or environmental pollutants like BPA (bisphenol-A), an ingredient in many plastic products and food containers such as canned foods, that seeps into the food supply.

    Food intolerance or food allergies can also contribute to prostatitis. The symptoms of a food intolerance or allergy may include vomiting, diarrhea, nausea, or abdominal pain. If you have a food intolerance you may also experience gas, bloating, headache,
    cramps, irritability, and nervousness. A food allergy is an immune system response, and the symptoms generally can affect the entire body. In addition to the symptoms already named, a food allergy can cause hives, itchy skin, shortness of breath, a
    sudden drop in blood pressure, and difficulty swallowing. Food intolerance symptoms can be uncomfortable, but food allergy symptoms can be life threatening.

    It can be challenging to identify an allergy or food intolerance. You may not react to a particular food for a few hours or even days. Your reaction may be a worsening of prostatitis symptoms instead of the common symptoms you would associate with an
    intolerance or allergy.

    If you think that a food allergy or intolerance could be contributing to your prostatitis symptoms, try an elimination diet or consider undergoing allergy testing. Some tests like the ALCAT test do throw out false positives and can be costly, so trying
    an elimination diet might be a good start.

    Many men find that going on a wheat-free diet or trying a gluten-free diet can help them manage their prostatitis symptoms. Wheat and a protein in wheat called gluten can cause inflammation, which can damage the body and cause illness. A gluten-free diet
    avoids barley, malt, triticale, and wheat.

    In general, it is important to eat a healthy diet as part of managing your prostatitis. Avoid foods that commonly are associated with triggering prostatitis and try to include plenty of whole and natural foods such as the following:

    Vegetables, especially cruciferous vegetables
    Fruits (but avoid acidic fruits if they affect your prostatitis)
    High-quality protein (plant protein is better than animal)
    Foods high in zinc or zinc supplements
    Omega-3 fatty acids and healthy fats found in the Mediterranean diet
    Foods high in fiber
    Following the Mediterranean diet can help you reduce inflammation in your body. Reduce the red meat you eat and instead opt for fish, beans, lentils, and nuts, which are all low in saturated fat and cholesterol. Eat foods high in zinc, omega-3 fatty
    acids, and lycopene, but if acidic tomatoes or fruits are a problem for your prostate try eliminating them. It is important to stay well hydrated with water, but you should avoid drinks like soda and caffeinated coffee or tea, which have been shown to
    exacerbate prostatitis symptoms. You should also limit or avoid alcohol, which can make symptoms worse.

    Studies have shown that certain foods may help improve prostatitis symptoms. Foods and supplements that may help with prostate and urinary health include the following:

    Calcium glycerophosphate (neutralizes acidic foods)
    Docusate (softens stools)
    Psyllium (fiber), polycarbophil (laxative)
    Water
    Baking soda
    As you can see, some of the things that have helped prostatitis patients in studies also affect bowel health, which is why daily use of probiotics is also key when considering diet for prostatitis. By getting your diet under control and eliminating foods
    that could be causing your prostatitis symptoms, you are going to feel a lot better as a whole.

    Editor’s comment:
    Generally following a diet like the Mediterranean diet will help reduce inflammation and promote healthy bacteria and immunity. The Mediterranean diet also has many other benefits for heart, prostate, and general health. Try and limit alcohol to 1-2
    glasses a day. Any more than that has been shown to negatively affect prostate health. Eat organic as much as possible within your budget. Make it a point of getting regular exercise to keep your weight under control as that will also help reduce
    inflammation.




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    Can I Have Sex With Prostatitis?
    Overcoming Depression with Prostatitis
    Diet for Prostatitis
    Products and Devices to Help With Prostatitis
    Wheat-Free Diet for Prostatitis
    Foods to Avoid for Prostatitis
    Chemicals That Can Cause Prostatitis

    Prostatitis and Pelvic Pain News

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    http://prostatitis.net/living-with-prostatitis/diet-for-prostatitis/



    On Wednesday, July 12, 2017 at 12:54:07 AM UTC-5, II wrote:
    Urology. 2016 Jun;92:26-32. doi: 10.1016/j.urology.2016.02.043. Epub 2016 Mar 9.

    The Urinary Microbiome Differs Significantly Between Patients With Chronic Prostatitis/Chronic Pelvic Pain Syndrome and Controls as Well as Between Patients With Different Clinical Phenotypes.

    Shoskes DA1, Altemus J2, Polackwich AS3, Tucky B3, Wang H4, Eng C5.
    Author information
    Abstract
    OBJECTIVE:
    To study the urinary microbiome of patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) compared with controls.
    METHODS:
    We identified 25 patients with CP/CPPS and 25 men who were either asymptomatic or only had urinary symptoms. Midstream urine was collected. Symptom severity was measured with the National Institutes of Health Chronic Prostatitis Symptom Index and
    clinical phenotype with UPOINT. Total DNA was extracted from the urine pellet and bacterial-specific 16Sr-DNA-capture identified by MiSeq sequencing. Taxonomic and functional bioinformatic analyses used principal coordinate analysis (PCoA)/MacQIIME,
    LEfSe, and PiCRUSt algorithms.
    RESULTS:
    Patients and controls were similar ages (52.3 vs 57.0 years, P = .27). For patients, median duration was 48 months, mean Chronic Prostatitis Symptom Index was 26.0, and mean UPOINT domains was 3.6. Weighted 3D UniFrac PCoA revealed tighter
    clustering of controls distinct from the wider clustering of cases (P = .001; α-diversity P = .005). Seventeen clades were overrepresented in patients, for example, Clostridia, and 5 were underrepresented, eg, Bacilli, resulting in predicted
    perturbations in functional pathways. PiCRUSt inferred differentially regulated pathways between cases and controls that may be of relevance including sporulation, chemotaxis, and pyruvate metabolism. PCoA-derived microbiomic differences were noted for
    neurologic/systemic domains (P = .06), whereas LEfSe identified differences associated with each of the 6 clinical features.
    CONCLUSION:
    Urinary microbiomes from patients with CP/CPPS have significantly higher alpha(phylogenetic) diversity which cluster differently from controls, and higher counts of Clostridia compared with controls, resulting in predicted perturbations of functional
    pathways which could suggest metabolite-specific targeted treatment. Several measures of severity and clinical phenotype have significant microbiome differences.
    Copyright © 2016 Elsevier Inc. All rights reserved.
    PMID: 26970449 DOI: 10.1016/j.urology.2016.02.043

    https://www.ncbi.nlm.nih.gov/pubmed/26970449

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