• Iron In Gestational Diabetes Mellitus

    From ironjustice@21:1/5 to All on Mon Dec 10 06:35:05 2018
    Iron-Related Factors in Early Pregnancy and Subsequent Risk of Gestational Diabetes Mellitus: the Ma'anshan Birth Cohort (MABC) Study.
    Zhu B1,2, Liang C1,2, Xia X1,2, Huang K1,2, Yan S3, Hao J1,2, Zhu P1,2, Gao H1, Tao F4,5.
    Biol Trace Elem Res. 2018 Dec 5. doi: 10.1007/s12011-018-1595-4.
    Abstract
    Iron is an essential micronutrient while its excessive load has been related to the etiology of diabetes. We used data of 3289 pregnant women from the Ma'anshan birth cohort (MABC) study in China to examine the associations of three iron-related factors (
    i.e., serum iron (SI) concentration, hemoglobin level, and use of iron supplements) with risk of gestational diabetes mellitus (GDM). Emphatically explore the potential non-linear relationship between SI concentration and risk of GDM. SI concentration
    was measured in fasting blood using inductively coupled plasma mass spectrometry (ICP-MS). GDM diagnosis was determined by 75 g oral glucose tolerance test at 24~28 weeks. Restricted cubic splines with three knots were used to examine potential non-
    linear relationship between SI concentration and GDM risk. We observed a U-shape relation between SI concentration in the first trimester and risk of GDM. In the multivariate-adjusted model, compared with the middle level (ln(SI), 7.1-7.7 μg/L), both
    the lowest level (ln(SI) ≤ 7.1 μg/L) (odds ratio (OR) = 1.35, 95% confidence interval (CI) = 1.04-1.76) and the highest level (ln(SI) > 7.7 μg/L) (OR = 1.63, 95%CI = 1.16-2.28) increased risk of GDM. Associations of hemoglobin
    level in the first trimester and risk of GDM attenuated to non-significance after adjustment for pre-pregnancy body mass index (BMI) and blood pressure. Pre-pregnancy iron supplement use was associated with an increased risk of GDM (OR = 1.57, 95%CIâ€
    ‰= 1.06-2.32). In conclusion, the three iron-related factors are all related to GDM risk on some level.

    KEYWORDS:
    Gestational diabetes mellitus; Hemoglobin; Iron supplements; Non-linear relationship; Serum iron concentration

    PMID: 30515713 DOI: 10.1007/s12011-018-1595-4

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