Iron: an essential nutrient for Aspergillus fumigatus and a fulcrum for pathogenesis.
Matthaiou EI1, Sass G2, Stevens DA2,3, Hsu JL1.
Curr Opin Infect Dis. 2018 Dec;31(6):506-511. doi: 10.1097/QCO.0000000000000487.

Abstract
PURPOSE OF REVIEW:
Aspergillus fumigatus is a ubiquitous saprophytic fungus that can cause life-threatening invasive aspergillosis in immunocompromised patients. Apart from the immune status of the host only a few characterized virulence factors have been identified. In
this review, we describe the role of iron in the manifestation of A. fumigatus virulence.

RECENT FINDINGS:
We gathered recent clinical evidence suggesting that tissue iron overload increases the risk of invasive aspergillosis occurrence. Furthermore, we summarize the mechanisms that A. fumigatus employs to achieve iron homeostasis and their importance in A.
fumigatus proliferation in vitro. We describe two recent in-vivo models that clearly demonstrate the importance of iron in A. fumigatus growth and invasion.

SUMMARY:
Based on these recent findings, therapy aimed at managing A. fumigatus iron homeostasis locally could make conditions more favorable to the host.

PMID: 30379731 DOI: 10.1097/QCO.0000000000000487

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/634q5a

Man Is A Herbivore!
http://tinyurl.com/4rq595

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

--- SoupGate-Win32 v1.05
* Origin: fsxNet Usenet Gateway (21:1/5)