Editorial commentary
CSF ferritin predicts CSF Aβ decline in biomarker-determined Alzheimer’s disease
James R Connor
Correspondence to
Dr James R Connor, Department of Neurosurgery, Penn State Hershey Medical Center, Hershey, PA 17033, USA; jconnor at pennstatehealth.psu.edu
http://dx.doi.org/10.1136/jnnp-2017-317050

CSF ferritin relationship to CSF Aβ could be used to identify AD patients for iron chelation therapy
This JNNP paper by an excellent team of investigators1 has built on many years of study that has shown loss of iron homeostasis in brain of persons with Alzheimer’s disease (AD). As the authors pointed out, iron has been identified with amyloid plaques
and has been suggested to promote neurodegenerative processes through inflammation and generation of oxidative stress.2 There is also a considerable literature on amyloid precursor protein (APP) and iron handling in the brain including the presence of
an iron-responsive element on the APP messenger RNA.3 Therefore, iron is clearly implicated in AD pathology and pathogenic processes.

http://jnnp.bmj.com/content/89/5/445?rss=1

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Tom


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