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  • Iron In Hypertension

    From ironjustice@21:1/5 to All on Fri Feb 9 09:57:25 2018
    Influence of dietary iron intake restriction on the development of hypertension in weanling prehypertensive rats.
    Okuno K1, Naito Y2, Yasumura S1, Sawada H1, Oboshi M1, Nishimura K1, Asakura M1, Ishihara M3, Masuyama T1.
    Heart Vessels. 2018 Feb 7. doi: 10.1007/s00380-018-1134-4.
    Abstract
    Hypertension is a major public health problem leading to death. To reduce the morbidity and mortality in patients with hypertension, it is crucial to develop a novel strategy for prevention of hypertension. We have currently reported an attempt at
    dietary iron intake restriction as non-pharmacological treatment of hypertension in patients with hypertension. However, it remains fully unknown whether dietary iron restriction prevents the development of hypertension. We investigated the influence of
    dietary iron restriction on the development of hypertension in weanling pre-hypertensive model rats. 3-week-old male stroke-prone spontaneously hypertensive rats (SHR-SP) were randomly divided into two groups and were given an ad libitum normal diet or
    an iron-restricted diet for 12 weeks. Blood pressure was progressively increased in SHR-SP according to growth, while dietary iron restriction attenuated the development of hypertension. Proteinuria was also increased in SHR-SP according to growth,
    whereas dietary iron restriction suppressed the increment of proteinuria. SHR-SP exhibited glomerulosclerosis and exacerbated renal interstitial fibrosis at 15 weeks old, indicating that SHR-SP developed hypertensive nephropathy in the adult stage;
    however, these changes were attenuated by dietary iron restriction. Gelatin zymography showed dietary iron restriction decreased both renal MMP-2 and MMP-9 activities in SHR-SP at 15 weeks old. Of interest, dietary iron restriction suppressed renal TGFβ-
    RI expression and Smad2 phosphorylation in SHR-SP. Furthermore, dietary iron restriction decreased renal fibrosis, renal MMP-2 and MMP-9 activities, renal TGFβ-RI expression, and Smad2 phosphorylation in rats with unilateral ureteral obstruction.
    Dietary iron restriction prevented the development of hypertension in weanling pre-hypertensive rats.

    KEYWORDS:
    Hypertension; Hypertensive nephropathy; Iron restriction; Renal fibrosis

    PMID: 29417224 DOI: 10.1007/s00380-018-1134-4


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