Increased Hepatic Iron Content Predicts Poor Survival in Patients With Iron Overload Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation
Clinical Lymphoma Myeloma and Leukemia
Volume 16, Supplement, August 2016, Pages S10–S18
Proceedings of the Society of Hematologic Oncology 2015 Annual Meeting
SOHO Supplement 2016
Serdar Sivgin1, , , Suleyman Baldane1, Kemal Deniz2, Gokmen Zararsiz3, 4, Leylagul Kaynar1, Mustafa Cetin1, Ali Unal1, Bulent Eser1
doi:10.1016/j.clml.2016.02.005

Iron overload results in increased infection, venous-oclusive disease and hepatic dysfunction in allogeneic hematopoietic stem cell transplant (alloHSCT) recipients. Liver is one of the most common sites of iron overload.

Patients and Methods
A total of 50 alloHSCT recipients that underwent liver biopsy in Erciyes Stem Cell Transplantation Hospital, Erciyes University, between 2004 and 2011 were enrolled in the study. The liver biopsy specimens have been obtained from the archives of Erciyes
University, Department of Pathology and stainned for iron content.

Results
The mean age was found 34 ± 11 years. For median overall survival (OS); 53 months (min-max: 41-65) in patients with grade 0, 55 months (min-max: 47-64) in patients with grade 1, in patients with grade 2 patients 25.4 months (11.5-39.4 ), grade 3
patients 29.3 months (min-max: 12.3-46.3) and grade 4 patients 2.6 months (min-max: 2.0-3.3). Overall survival was correlated with the degree of liver iron content and it was statistically significant in Kaplan-Meier analysis (P < .001). Disease-free
survival was found (DFS); grade 0 patients 47.1 months (min-max: 32.0-62.0), grade 1 patients 36.9 months (min-max: 21.0-65.0), grade 2 patients 23.5 months (min-max: 12.0-59.0), grade 3 patients 27.4 months (min-max: 5.3-59.3) and grade 4 patients 2.6
months (min-max: 2.0-3.0). For DFS; it was negatively correlated with the degree of liver iron content nevertheless; it was not was statistically significant in Kaplan-Meier analysis (P = .093).Hepatic iron overload might be associated with poor survival
in patients with transfusional iron overload that underwent alloHSCT.

Conclusion
Hepatic iron content might be associated with poorer prognosis in patients with iron overload that underwent alloHSCT.

Keywords
Allogeneic hematopoietic stem cell transplantation; Ferritin; Hepatic iron overload; Survival
Address for correspondence: Serdar Sivgin, MD, Dedeman Stem Cell Transplantation Hospital, Department of Hematology, Talas St, 38280 Kayseri, Talas, Turkey. Fax: +90 3524379348
© 2016 Elsevier Inc. All rights reserved.

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://tinyurl.com/634q5a

Man Is A Herbivore!
http://tinyurl.com/4rq595

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

--- SoupGate-Win32 v1.05
* Origin: fsxNet Usenet Gateway (21:1/5)