Iron and dopamine: a toxic couple.
Hare DJ1, Double KL2.
Brain. 2016 Mar 8. pii: aww022.
Abstract
Iron accumulation is a cardinal feature of degenerating regions in the Parkinson's disease brain. As a potent pro-oxidant, redox-active iron may be a key player in upstream mechanisms that precipitate cell death in this disorder. Although an elevation in
brain iron levels is a normal feature of ageing, the increase is greater in Parkinson's disease; on the other hand, the effects of the disease are most marked in the nigrostriatal dopaminergic system. In this Update, we explain that neurodegeneration in
the affected regions may result from the potent redox couple formed by iron and dopamine itself, and discuss the clinical implications of this molecular trait in this dynamic and rapidly moving area of Parkinson's disease research.
(c) The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved.
KEYWORDS:
Parkinson's disease; alpha-synuclein; cellular mechanisms; neurodegeneration; oxidative stress
PMID: 26962053
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