• Iron In COVID-19

    From ironjustice@21:1/5 to All on Sat Oct 9 15:25:05 2021
    Increased serum catalytic iron may mediate tissue injury and death in patients with COVID-19
    Sci Rep
    . 2021 Oct 4;11(1):19618. doi: 10.1038/s41598-021-99142-x.
    Vipul Chakurkar 1, Mohan Rajapurkar 2, Suhas Lele 2, Banibrata Mukhopadhyay 2, Valentine Lobo 3, Ramakrishna Injarapu 4, Muddassir Sheikh 4, Bharatkumar Dholu 4, Arpita Ghosh 5 6, Vivekanand Jha 5 6 7

    PMID: 34608227 PMCID: PMC8490366 DOI: 10.1038/s41598-021-99142-x

    Abstract
    The pathophysiology and the factors determining disease severity in COVID-19 are not yet clear, with current data indicating a possible role of altered iron metabolism. Previous studies of iron parameters in COVID-19 are cross-sectional and have not
    studied catalytic iron, the biologically most active form of iron. The study was done to determine the role of catalytic iron in the adverse outcomes in COVID-19. We enrolled adult patients hospitalized with a clinical diagnosis of COVID-19 and measured
    serum iron, transferrin saturation, ferritin, hepcidin and serum catalytic iron daily. Primary outcome was a composite of in-hospital mortality, need for mechanical ventilation, and kidney replacement therapy. Associations between longitudinal iron
    parameter measurements and time-to-event outcomes were examined using a joint model. We enrolled 120 patients (70 males) with median age 50 years. The primary composite outcome was observed in 25 (20.8%) patients-mechanical ventilation was needed in 21 (
    17.5%) patients and in-hospital mortality occurred in 21 (17.5%) patients. Baseline levels of ferritin and hepcidin were significantly associated with the primary composite outcome. The joint model analysis showed that ferritin levels were significantly
    associated with primary composite outcome [HR (95% CI) = 2.63 (1.62, 4.24) after adjusting for age and gender]. Both ferritin and serum catalytic iron levels were positively associated with in-hospital mortality [HR (95% CI) = 3.22 (2.05, 5.07) and 1.73 (
    1.21, 2.47), respectively], after adjusting for age and gender. The study shows an association of ferritin and catalytic iron with adverse outcomes in COVID-19. This suggests new pathophysiologic pathways in this disease, also raising the possibility of
    considering iron chelation therapy.

    © 2021. The Author(s).

    Conflict of interest statement
    MR and SSL report holding United States and European patents for the methods and kit for the measurement of serum catalytic iron for early detection of acute coronary syndrome and prediction of adverse cardiac events. VJ reports grant support from GSK
    and Baxter and Advisory and Consultancy fees from Astra Zeneca, and Baxter Healthcare, outside of submitted work. He has a policy of all funds going to the employer. Other authors have no competing interests to declare.

    https://pubmed.ncbi.nlm.nih.gov/34608227/


    Who loves ya.
    Tom


    Jesus Was A Vegetarian!
    http://tinyurl.com/2r2nkh


    Man Is A Herbivore!
    http://tinyurl.com/4rq595


    DEAD PEOPLE WALKING
    http://tinyurl.com/zk9fk

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)