Review
Iron Pathways and Iron Chelation Approaches in Viral, Microbial, and Fungal Infections
Ravneet Chhabra 1, Aishwarya Saha 1, Ashkon Chamani 1, Nicole Schneider 1, Riya Shah 1, Meera Nanjundan 1
Pharmaceuticals (Basel). 2020 Sep 25;13(10):275.
PMID: 32992923 PMCID: PMC7601909 DOI: 10.3390/ph13100275
Free PMC article
Abstract
Iron is an essential element required to support the health of organisms. This element is critical for regulating the activities of cellular enzymes including those involved in cellular metabolism and DNA replication. Mechanisms that underlie the tight
control of iron levels are crucial in mediating the interaction between microorganisms and their host and hence, the spread of infection. Microorganisms including viruses, bacteria, and fungi have differing iron acquisition/utilization mechanisms to
support their ability to acquire/use iron (e.g., from free iron and heme). These pathways of iron uptake are associated with promoting their growth and virulence and consequently, their pathogenicity. Thus, controlling microorganismal survival by
limiting iron availability may prove feasible through the use of agents targeting their iron uptake pathways and/or use of iron chelators as a means to hinder development of infections. This review will serve to assimilate findings regarding iron and the
pathogenicity of specific microorganisms, and furthermore, find whether treating infections mediated by such organisms via iron chelation approaches may have potential clinical benefit.

Keywords: fungi; gram-negative bacteria; gram-positive bacteria; hepatitis C virus; human immunodeficiency virus; iron chelators; iron uptake pathways.

https://pubmed.ncbi.nlm.nih.gov/32992923/

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