ABSTRACT

Non-Typhi Salmonella (NTS) is one of the zoonotic pathogens that can cause contamination in feed ingredients and animal products, and then pose a critical threat to human and animal health. The mechanisms used by Salmonella to successfully infect poultry
still need to be determined to successfully develop mitigation strategies. The gut is the location where the Salmonella infection is initiated; therefore to reduce the risk of salmonellosis, preventing the colonization and invasion of Salmonella in the
gut is essential. This study aims to evaluate the roles of iron uptake in the survival, colonization and virulence of Salmonella in animal guts using Caco-2 cells and Caenorhabditis elegans (C. elegans) models. Our results suggest that iron chelators
inhibited the growth of wild-type and iron-uptake defective mutants of Salmonella. Iron uptake systems were required for the survival, colonization and virulence of Salmonella in C. elegans. These findings could help to develop natural compounds and
biocontrol agents (e.g. specific iron sources and iron chelators) based on iron uptake system proteins for controlling Salmonella to mitigate potential threats to public health, enhance consumer confidence in Canadian Agri-food products and reduce the
cost associated with foodborne illness.

https://mspace.lib.umanitoba.ca/jspui_org/bitstream/1993/33973/1/Tan_Zhigang.pdf


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