Transferrin-mediated iron sequestration as a novel therapy for bacterial and fungal infections.
Bruhn KW1, Spellberg B2.
Curr Opin Microbiol. 2015 Aug 8;27:57-61. doi: 10.1016/j.mib.2015.07.005. 1Department of Molecular Microbiology & Immunology, Keck School of Medicine at the University of Southern California (USC), Los Angeles, CA, United States. Electronic address: kbruhn at usc.edu.2Department of Medicine, Keck School of Medicine at USC, Los
Angeles, United States.

Abstract

Pathogenic microbes must acquire essential nutrients, including iron, from the host in order to proliferate and cause infections. Iron sequestration is an ancient host antimicrobial strategy. Thus, enhancing iron sequestration is a promising, novel anti-
infective strategy. Unfortunately, small molecule iron chelators have proven difficult to develop as anti-infective treatments, in part due to unacceptable toxicities. Iron sequestration in mammals is predominantly mediated by the transferrin family of
iron-binding proteins. In this review, we explore the possibility of administering supraphysiological levels of exogenous transferrin as an iron sequestering therapy for infections, which could overcome some of the problems associated with small molecule
chelation. Recent studies suggest that transferrin delivery may represent a promising approach to augment both natural resistance and traditional antibiotic therapy.
Copyright © 2015 Elsevier Ltd. All rights reserved.

PMID:26261881

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