• Re: Bleeding Therapy

    From ironjustice@21:1/5 to ensoul on Thu Sep 23 20:55:19 2021
    On Saturday, July 25, 2009 at 4:46:27 PM UTC-6, ensoul wrote:
    On Jul 20, 1:24 pm, ironjustice <@hotmail.com> wrote:
    Discussion on the suitable diseases and symptoms of bleeding therapy Zhongguo Zhen Jiu. 2009 May;29(5):397-9.
    Chen B, Gao C, Li C, Chen ZL, Guo Y.
    Tianjin University of Traditional Chinese Medicine, Tianjin 300193,
    China.

    In order to explore the suitable diseases and symptoms treated by
    bleeding therapy so as to guide the clinical practice.
    The retrospective study of periodical literature series is used
    and all clinical literatures about bleeding therapy were searched
    in the China Journal Full Text Database in CNKI, the VIP Chinese
    Scientific Journals Full Text Database (CSJD), Wanfang Database,
    and the Chinese Bio-medical Literature Database, and the frequency
    of the literature and the total cases treated with bleeding therapy
    were statistically analyzed, and the principles and methods of
    clinical epidemiology and evidence-based medicine were used to
    classify and grade the literatures, and the diseases were classified according to the international statistical classification about
    diseases and related healthy problems (ICD10) issued by World
    Health Organization.
    As a result, 1149 effective literatures including 98,526 cases
    were searched out, which were involved in 18 major systems and
    261 kinds of diseases. It is indicated that the bleeding therapy
    has lots of suitable diseases and symptoms and it is worth to be popularized.
    Particularly, this therapy has obvious advantages for treatment
    of herpes zoster, acne, hordeolum, cervical spondylosis, and
    oral ulcer.

    PMID: 19489499

    Who loves ya.
    Tom

    Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh

    Man Is A Herbivore!http://tinyurl.com/a3cc3

    DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
    Iron Man you that last URL you have listed is offense! To even
    suggest that there's diet for that type cancer, is pure fraud, there
    no treatment for it, you die from it as Rick did

    Seems targeting iron is a method to try ..

    “iron elimination from the mesothelial environment can confer dual merits for preventing asbestos-induced mesothelical carcinogenesis by suppressing inflammation and mesothelial proliferation simultaneously”

    Cancer Sci
    . 2016 Jul;107(7):908-15. doi: 10.1111/cas.12947. Epub 2016 Jun 13.
    Dual preventive benefits of iron elimination by desferal in asbestos-induced mesothelial carcinogenesis
    Li Jiang 1, Shan-Hwu Chew 1, Kosuke Nakamura 1, Yuuki Ohara 1, Shinya Akatsuka 1, Shinya Toyokuni 1
    Affiliations expand
    PMID: 27088640 PMCID: PMC4946728 DOI: 10.1111/cas.12947
    Free PMC article
    Abstract
    Asbestos-induced mesothelial carcinogenesis is currently a profound social issue due to its extremely long incubation period and high mortality rate. Therefore, procedures to prevent malignant mesothelioma in people already exposed to asbestos are
    important. In previous experiments, we established an asbestos-induced rat peritoneal mesothelioma model, which revealed that local iron overload is a major cause of pathogenesis and that the induced genetic alterations are similar to human counterparts.
    Furthermore, we showed that oral administration of deferasirox modified the histology from sarcomatoid to the more favorable epithelioid subtype. Here, we used i.p. administration of desferal to evaluate its effects on asbestos-induced peritoneal
    inflammation and iron deposition, as well as oxidative stress. Nitrilotriacetate was used to promote an iron-catalyzed Fenton reaction as a positive control. Desferal significantly decreased peritoneal fibrosis, iron deposition, and nuclear 8-hydroxy-2'-
    deoxyguanosine levels in mesothelial cells, whereas nitrilotriacetate significantly increased all of them. Desferal was more effective in rat peritoneal mesothelial cells to counteract asbestos-induced cytotoxicity than in murine macrophages (RAW264.7).
    Furthermore, rat sarcomatoid mesothelioma cells were more dependent on iron for proliferation than rat peritoneal mesothelial cells. Because inflammogenicity of a fiber is proportionally associated with subsequent mesothelial carcinogenesis, iron
    elimination from the mesothelial environment can confer dual merits for preventing asbestos-induced mesothelial carcinogenesis by suppressing inflammation and mesothelial proliferation simultaneously.

    Keywords: Asbestos; chelator; desferal; iron; mesothelioma.

    © 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.


    “Iron overload as a major targetable pathogenesis of asbestos-induced mesothelial carcinogenesis”

    Redox Rep
    . 2014 Jan;19(1):1-7. doi: 10.1179/1351000213Y.0000000075. Epub 2013 Nov 20. Iron overload as a major targetable pathogenesis of asbestos-induced mesothelial carcinogenesis
    Shinya Toyokuni
    PMID: 24257681 PMCID: PMC6837658 DOI: 10.1179/1351000213Y.0000000075
    Free PMC article
    Abstract
    Few people expected that asbestos, a fibrous mineral, would be carcinogenic to humans. In fact, asbestos is a definite carcinogen in humans, causing a rare but aggressive cancer called malignant mesothelioma (MM). Mesothelial cells line the three somatic
    cavities and thus do not face the outer surface, but reduce the friction among numerous moving organs. MM has several characteristics: extremely long incubation period of 30-40 years after asbestos exposure, difficulty in clinical diagnosis at an early
    stage, and poor prognosis even under the current multimodal therapies. In Japan, 'Kubota shock' attracted considerable social attention in 2005 for asbestos-induced mesothelioma and, thereafter, the government enacted a law to provide the people
    suffering from MM a financial allowance. Several lines of recent evidence suggest that the major pathology associated with asbestos-induced MM is local iron overload, associated with asbestos exposure. Preclinical studies to prevent MM after asbestos
    exposure with iron reduction are in progress. In addition, novel target genes in mesothelial carcinogenesis have been discovered with recently recognized mesothelioma-prone families. Development of an effective preventive strategy is eagerly anticipated
    because of the long incubation period for MM.

    Keywords: Asbestos; CDKN2A/2B; Iron chelation; Iron overload; Malignant mesothelioma; Phlebotomy.

    "Our results indicate that appropriate phlebotomy may be a practical preventive measure to attenuate the initiation and promotion capacity of asbestos towards MM by reducing iron in individuals exposed to asbestos."

    2018 Feb;109(2):330-339. doi: 10.1111/cas.13460. Epub 2018 Jan 4.
    Phlebotomy as a preventive measure for crocidolite-induced mesothelioma in male rats
    Yuuki Ohara 1, Shan-Hwu Chew 1, Takahiro Shibata 1, Yasumasa Okazaki 1, Kyoko Yamashita 1, Shinya Toyokuni 1 2
    Affiliations expand
    PMID: 29193587 PMCID: PMC5797813 DOI: 10.1111/cas.13460
    Free PMC article
    Abstract
    Malignant mesothelioma (MM) is a rare but socially important neoplasm due to its association with asbestos exposure. Malignant mesothelioma is difficult to diagnose at an early stage, yet there are no particularly effective treatments available at the
    advanced stage, thus necessitating efficient strategies to prevent MM in individuals already exposed to asbestos. We previously showed that persistent oxidative damage caused by foreign body reaction and affinity of asbestos both to hemoglobin and
    histones is one of the major pathogeneses. Accordingly, as an effective strategy to prevent asbestos-induced MM, we undertook the use of an iron chelator, deferasirox, which decreased the epithelial-mesenchymal transition in a crocidolite-induced rat MM
    model. However, this agent may show adverse effects. Here, we studied the effects of iron removal by phlebotomy as a realistic measure on the same rat model. We injected a total of 5 mg crocidolite i.p. to F1 hybrid rats between the Fischer-344 and Brown-
    Norway strains at the age of 6 weeks. We repeated weekly or biweekly phlebotomy of 6-8 mL/kg/time from 10 to 60 weeks of age. The animals were observed until 120 weeks. In male rats, phlebotomy significantly decreased the weight and nuclear grade of MM,
    and modestly reduced the associated ascites and the fraction of more malignant sarcomatoid subtype. Weekly phlebotomy prolonged long-term survival. Our results indicate that appropriate phlebotomy may be a practical preventive measure to attenuate the
    initiation and promotion capacity of asbestos towards MM by reducing iron in individuals exposed to asbestos.

    Keywords: asbestos; malignant mesothelioma; oxidative stress; phlebotomy; prevention.

    © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.


    Who loves ya.
    Tom


    Jesus Was A Vegetarian!
    http://tinyurl.com/2r2nkh


    Man Is A Herbivore!
    http://tinyurl.com/4rq595


    DEAD PEOPLE WALKING
    http://tinyurl.com/zk9fk

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