Increased Serum Levels of Hepcidin and Ferritin Are Associated with Severity of COVID-19
Cuixing Zhou,1,B,C,D,E Yimeng Chen,1,A,B,C Yun Ji,2,B,C Xiaozhou He,corresponding author1,A,F and Dong Xue
Med Sci Monit. 2020; 26: e926178-1–e926178-6.
Published online 2020 Sep 26. Prepublished online 2020 Aug 11.
doi: 10.12659/MSM.926178
PMCID: PMC7526336
PMID: 32978363
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526336/
Abstract
Background
The aim of this study was to assess the diagnostic utility of iron homeostasis determinations for prediction of severity of COVID-19.
Material/Methods
This was a retrospective study enrolling a total of 50 patients diagnosed with the novel coronavirus disease-19 (COVID-19) from February 27, 2020 to March 30, 2020, including a severe group (12 patients) and a mild group (38 patients). For the control
group, 50 healthy people were examined during the same period. We compared clinical laboratory data and iron homeostasis biomarkers among the 3 groups. ROC curve analysis was used to assess diagnoses.
Results
Patients diagnosed with severe COVID-19 had higher hepcidin and serum ferritin levels than in other groups (p<0.001). A combination test of hepcidin and serum ferritin provided the best specificity and sensitivity in the prognosis of COVID-19 severity.
Logistic regression analysis showed hepcidin and serum ferritin independently contributed to the severity of COVID-19. Hepcidin and serum ferritin tandem testing predicted COVID-19 severity with 94.6% specificity, while hepcidin and serum ferritin
parallel testing had a sensitivity of 95.7%.
Conclusions
Iron homeostasis had a robust association with the occurrence of severe COVID-19. Iron homeostasis determinations were specific and sensitive for the early prediction of disease severity in COVID-19 patients and thus have clinical utility.
MeSH Keywords: COVID-19, Hepcidins, Iron Metabolism Disorders
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