• Iron In COVID-19 Severity

    From ironjustice@21:1/5 to All on Fri Oct 23 04:58:40 2020
    Increased Serum Levels of Hepcidin and Ferritin Are Associated with Severity of COVID-19
    Cuixing Zhou,1,B,C,D,E Yimeng Chen,1,A,B,C Yun Ji,2,B,C Xiaozhou He,corresponding author1,A,F and Dong Xue
    Med Sci Monit. 2020; 26: e926178-1–e926178-6.
    Published online 2020 Sep 26. Prepublished online 2020 Aug 11.
    doi: 10.12659/MSM.926178
    PMCID: PMC7526336
    PMID: 32978363

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526336/

    Abstract
    Background
    The aim of this study was to assess the diagnostic utility of iron homeostasis determinations for prediction of severity of COVID-19.

    Material/Methods
    This was a retrospective study enrolling a total of 50 patients diagnosed with the novel coronavirus disease-19 (COVID-19) from February 27, 2020 to March 30, 2020, including a severe group (12 patients) and a mild group (38 patients). For the control
    group, 50 healthy people were examined during the same period. We compared clinical laboratory data and iron homeostasis biomarkers among the 3 groups. ROC curve analysis was used to assess diagnoses.

    Results
    Patients diagnosed with severe COVID-19 had higher hepcidin and serum ferritin levels than in other groups (p<0.001). A combination test of hepcidin and serum ferritin provided the best specificity and sensitivity in the prognosis of COVID-19 severity.
    Logistic regression analysis showed hepcidin and serum ferritin independently contributed to the severity of COVID-19. Hepcidin and serum ferritin tandem testing predicted COVID-19 severity with 94.6% specificity, while hepcidin and serum ferritin
    parallel testing had a sensitivity of 95.7%.

    Conclusions
    Iron homeostasis had a robust association with the occurrence of severe COVID-19. Iron homeostasis determinations were specific and sensitive for the early prediction of disease severity in COVID-19 patients and thus have clinical utility.

    MeSH Keywords: COVID-19, Hepcidins, Iron Metabolism Disorders


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