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  • Iron In Neonatal Hypoxia-induced Seizures

    From ironjustice@21:1/5 to All on Fri Oct 23 04:53:03 2020
    Attenuation of the mutual elevation of iron accumulation and oxidative stress may contribute to the neuroprotective and anti-seizure effects of xenon in neonatal hypoxia-induced seizures
    Free Radic Biol Med
    2020 Oct 16;S0891-5849(20)31284-3. doi: 10.1016/j.freeradbiomed.2020.09.030. Mengdi Zhang 1, Yaru Cui 1, Wei Zhu 2, Jie Yu 1, Yao Cheng 1, Xiangdong Wu 1, Jinjin Zhang 1, Wenyu Xin 1, Yan Yu 1, Hongliu Sun 3
    PMID: 33075502 DOI: 10.1016/j.freeradbiomed.2020.09.030
    Abstract
    Previous studies have suggested that xenon inhalation has neuroprotective and antiepileptic effects; however, the underlying mechanisms involved remain unclear. This study aimed to investigate the possible xenon inhalation mechanisms involved in the
    neuroprotection and antiepileptic effects. A neonatal hypoxic C57BL/6J mouse model was used for the experiments. Immediately after hypoxia treatment, the treatment group inhaled a xenon mixture (70% xenon/21% oxygen/9% nitrogen) for 60 min, while the
    hypoxia group inhaled a non-xenon mixture (21% oxygen/79% nitrogen) for 60 min. Seizure activity was recorded at designated time points using electroencephalography. Oxidative stress levels, iron levels, neuronal injury, and learning and memory functions
    were also studied. The results showed that hypoxia increased the levels of iron, oxidative stress, mitophagy, and neurodegeneration, which were accompanied by seizures and learning and memory disorders. In addition, our results confirmed that xenon
    treatment significantly attenuated the hypoxia-induced seizures and cognitive defects in neonatal C57 mice. Moreover, the increased levels of iron, oxidative stress, mitophagy, and neuronal injury were reduced in xenon-treated mice. This study confirms
    the significant protective effects of a xenon mixture on hypoxia-induced damage in neonatal mice. Furthermore, our results suggest that reducing oxidative stress levels and iron accumulation may be the underlying mechanisms of xenon activity. Studying
    the protective mechanisms of xenon will advance its applications in potential therapeutic strategies.

    Keywords: iron stress; neonatal hypoxia; oxidative stress; xenon.

    Copyright © 2020 Elsevier Inc. All rights reserved.


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