Iron and inflammation: in vivo and post-mortem studies in Parkinson's disease
J Neural Transm (Vienna)
. 2020 Oct 20. doi: 10.1007/s00702-020-02271-2.
Antonio Martin-Bastida 1 2, Bension Shlomo Tilley 3, Sukhi Bansal 4, Steve M Gentleman 3, David T Dexter 3, Roberta J Ward 3
PMID: 33079260 DOI: 10.1007/s00702-020-02271-2
Abstract
In these present studies, in vivo and and post-mortem studies have investigated the association between iron and inflammation. Early-stage Parkinson's disease (PD) patients, of less than 5 years disease duration, showed associations of plasmatic ferritin
concentrations with both proinflammatory cytokine interleukin-6 and hepcidin, a regulator of iron metabolism as well as clinical measures. In addition ratios of plasmatic ferritin and iron accumulation in deep grey matter nuclei assessed with relaxometry
T2* inversely correlated with disease severity and duration of PD. On the hand, post-mortem material of the substantia nigra compacta (SNc) divided according to Braak and Braak scores, III-IV and V-VI staging, exhibited comparable microgliosis, with a
variety of phenotypes present. There was an association between the intensity of microgliosis and iron accumulation as assayed by Perl's staining in the SNc sections. In conclusion, markers of inflammation and iron metabolism in both systemic and brain
systems are closely linked in PD, thus offering a potential biomarker for progression of the disease.

Keywords: Cytokines; Ferritin; Hepcidin; Interleukin-6; Iron accumulation; Microglia; Neurodegeneration.


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