In vitro and in vivo effects of iron on the expression and activity of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase in rat spleen.
J Biochem Mol Toxicol. 2018 Dec 1:e22229. doi: 10.1002/jbt.22229.
Gonul Baltaci N1, Guler C2, Ceylan H1, Kalin SN1, Adem S2, Kocpinar EF1,3, Erdogan O1, Budak H1.

Abstract
Iron is an indispensable element for vital activities in almost all living organisms. It is also a cofactor for many proteins, enzymes, and other essential complex biochemical processes. Therefore, iron trafficking is firmly regulated by Hepcidin (Hamp),
which is regarded as the marker for iron accumulation. The disruption of iron homeostasis leads to oxidative stress that causes various human diseases, but this mechanism is still unclear. The aim of this study is to provide a better in vivo and in vitro
understanding of how long-term iron overload affects the gene expression and activities of some antioxidant enzymes, such as glucose 6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGD), and glutathione reductase (GR) in the spleen.
The findings of this study show that iron overload reduces the gene expression of G6pd, 6pgd, and Gr, but its actual effect was on the protein level.

KEYWORDS:
antioxidant enzymes; enzyme activity; iron overload; messenger RNA expression; rat spleen

PMID: 30506659 DOI: 10.1002/jbt.22229

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