• Nicotinamide Riboside as Treatment and/or Preventative Measure for Coro

    From MarcusAurelius@21:1/5 to All on Tue Mar 10 20:57:13 2020
    Nicotinamide Riboside increases NAD+ levels and improves immune system function. NAD+ levels fall dramatically with age."NAD+ levels markedly decline with age, creating an energy deficit that decreases the body’s ability to retain youthful function.
    To give you an idea how impactful NAD+ can be, by age 50 a typical person may have only half the NAD+ they did in youth. By age 80, NAD+ levels drop to only 1% to 10% expressed in youth.NAD+ is biologically unstable, which makes it unsuitable
    for oral supplementation.
    Fortunately, there is a solution.

    Oral Nicotinamide Riboside, NR, an NAD+ precursor vitamin, has "distinct and superior pharmokinetics to those of nicotinic acid and nicotinamide. We further show that single doses of 100,300, and 1,000 mg of NR produce dose-dependent increases in the
    blood NAD+ metabolome in the first clinical trial of NR pharmacokinetics in humans. We also report that nicotinic acid adenine dinucleotie (NAAD), which was not thought to be enroute for the conversion of NR to NAD+, is formed from NR and discover that
    the rise in NAAD is a highly sensitive biomarker of effective NAD+ repletion."
    NAD+ levels are intimately related to oxygenation and related functions at the cellular and tissue levels. Young people and children have relatively high levels of NAD+ and relatively good immune systems. The morbidity and mortality rate of the Corona
    virus increases significantly with age affecting most adversely the elderly. Thus, a reasonable hypothesis which I propose to treat and/or prevent the increased morbidity and mortality associated with infection by the Corona virus in the elderly is to
    administer orally and/or otherwise Nicotinamide Riboside."With advanced age, cell NAD+ levels plummet to near zero. Normal aging may one day be classified as “NAD+ deficiency syndrome.”Fortunately, there are proven ways to boost NAD+ levels." 11.
    Therefore, given the aforementioned, artificial means might be developed to enhance the enzymatic pathways both to NAD+ biosynthesis along with the biosynthesis of NMN.
    Oral ingestion of NMN and Nicotinamide Riboside supplements may prove useful. However, the biosynthesis of NAD+, NAD+ substitutes, NAD+ precursors, and NAD+ enzymatic utilization enzymes might prove to be an appropriate approach to effectively address the metabolic and physiological aging problems associated with the severe
    depletion of NAD+ associated with advanced age and infection with the Corona virus. The aforementioned is merely an unproven hypothesis on how Nicotinamide Riboside might be used as both a preventative measure and a treatment modality for infection with
    the Corona virus and diminishing both the morbidity and mortality associated with the same.

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