• Iron In Huntington's

    From ironjustice@21:1/5 to All on Tue Apr 17 18:19:54 2018
    Scientists find excess mitochondrial iron, Huntington's disease link

    https://medicalxpress.com/news/2018-04-scientists-excess-mitochondrial-iron-huntington.html

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  • From ironjustice@21:1/5 to All on Fri Jan 4 07:12:26 2019
    The Emerging Roles of Ferroptosis in Huntington's Disease.
    Mi Y1, Gao X1, Xu H1, Cui Y1, Zhang Y2, Gou X3.
    Neuromolecular Med. 2019 Jan 2. doi: 10.1007/s12017-018-8518-6.
    Abstract
    Huntington's disease (HD) is an autosomal dominant and fatal neurodegenerative disorder, which is caused by an abnormal CAG repeat in the huntingtin gene. Despite its well-defined genetic origin, the molecular mechanisms of neuronal death are unclear yet,
    thus there are no effective strategies to block or postpone the process of HD. Ferroptosis, a recently identified iron-dependent cell death, attracts considerable attention due to its putative involvement in neurodegenerative diseases. Accumulative data
    suggest that ferroptosis is very likely to participate in HD, and inhibition of the molecules and signaling pathways involved in ferroptosis can significantly eliminate the symptoms and pathology of HD. This review first describes evidence for the close
    relevance of ferroptosis and HD in patients and mouse models, then summarizes advances for the mechanisms of ferroptosis involved in HD, finally outlines some therapeutic strategies targeted ferroptosis. Comprehensive understanding of the emerging roles
    of ferroptosis in the occurrence of HD will help us to explore effective therapies for slowing the progression of this disease.

    KEYWORDS:
    Ferroptosis; Huntington’s disease; Iron accumulation; Lipid peroxidation; Mutant Huntingtin

    PMID: 30600476 DOI: 10.1007/s12017-018-8518-6

    Who loves ya.
    Tom

    Jesus Was A Vegetarian!
    http://tinyurl.com/634q5a

    Man Is A Herbivore!
    http://tinyurl.com/4rq595

    DEAD PEOPLE WALKING
    http://tinyurl.com/zk9fk

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