• Iron In Hair Damage

    From ironjustice@21:1/5 to All on Mon Feb 26 07:47:23 2018
    Demethylation of methionine and keratin damage in human hair
    Amino Acids
    pp 1–10
    Kamila Borowczyk, Joanna Suliburska, Hieronim Jakubowski
    First Online: 26 February 2018 https://link.springer.com/article/10.1007%2Fs00726-018-2545-3

    Growing human head hair contains a history of keratin and provides a unique model for studies of protein damage. Here, we examined mechanism of homocysteine (Hcy) accumulation and keratin damage in human hair. We found that the content of Hcy-keratin
    increased along the hair fiber, with levels 5–10-fold higher levels in older sections at the hair’s tip than in younger sections at hair’s base. The accumulation of Hcy led to a complete loss of keratin solubility in sodium dodecyl sulfate. The
    increase in Hcy-keratin was accompanied by a decrease in methionine-keratin. Levels of Hcy-keratin were correlated with hair copper and iron in older hair. These relationships were recapitulated in model experiments in vitro, in which Hcy generation from
    Met exhibited a similar dependence on copper or iron. Taken together, these findings suggest that Hcy-keratin accumulation is due to copper/iron-catalyzed demethylation of methionine residues and contributes to keratin damage in human hair.

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