Effects of Vitamin E on seizure frequency, electroencephalogram findings, and oxidative stress status of refractory epileptic patients.
Mehvari J1, Motlagh FG1, Najafi M1, Ghazvini MR2, Naeini AA3, Zare M1.
Adv Biomed Res. 2016 Mar 16;5:36. doi: 10.4103/2277-9175.178780. eCollection 2016.
Abstract
BACKGROUND:
Oxidative stress has been a frequent finding in epileptic patients receiving antiepileptic drugs (AEDs). In this study, the influence of Vitamin E on the antiseizure activity and redox state of patients treated with carbamazepine, sodium valproate, and
levetiracetam has been investigated.
MATERIALS AND METHODS:
This double-blind, placebo-controlled trial was carried out on 65 epileptic patients with chronic antiepileptic intake. The subjects received 400 IU/day of Vitamin E or placebo for 6 months. Seizure frequency, electroencephalogram (EEG), and redox state
markers were measured monthly through the study.
RESULTS:
Total antioxidant capacity, catalase and glutathione were significantly higher in Vitamin E received group compared with controls (P < 0.05) whereas malodialdehyde levels did not differ between two groups (P < 0.07). Vitamin E administration also caused
a significant decrease in the frequency of seizures (P < 0.001) and improved EEG findings (P = 0.001). Of 32 patients in case group, the positive EEG decreased in 16 patients (50%) whereas among 33 patients in control group only 4 patients (12.1%) showed
decreased positive EEG.
CONCLUSION:
The results of this preliminary study indicate that coadministration of antioxidant Vitamin E with AEDs improves seizure control and reduces oxidative stress.
KEYWORDS:
Carbamazpin; Vitamin E; electroencephalogram; epilepsy; levetiracetam; oxidative stress; sodium valproate
PMID: 27099849 PMCID: PMC4815530 DOI: 10.4103/2277-9175.178780
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