Improvement of chronic hepatitis B by iron chelation therapy in a patient with iron overload: A case report.
Zou DM1, Rong DD2, Zhao H1, Su L1, Sun WL1.
Medicine (Baltimore). 2017 Dec;96(52):e9566. doi: 10.1097/MD.0000000000009566. 1Department of Hematology.
2Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, P. R. China.
Abstract
RATIONALE:
This report describes seroconversion of hepatitis B surface antigen (HBsAg) in a patient with marked iron overload caused by chronic hepatitis B (CHB) after receiving iron chelation therapy and discusses the role of iron chelation therapy in CHB.
PATIENT CONCERNS:
Increased serum ferritin level for 2 months.
DIAGNOSIS:
Secondary iron overload and CHB.
INTERVENTION:
To relieve iron load of the body, the patient underwent regular phlebotomy therapy and deferoxamine (DFO) therapy. During the therapy, serum ferritin and hepatitis B virus (HBV) were monitored and the iron concentration of the liver and heart were
followed by T2* of magnetic resonance imaging (MRI) scan.
OUTCOMES:
Serum ferritin gradually decreased. Approximately 1 year after the therapy, HBsAg turned persistently negative.
LESSONS:
Iron chelation therapy may attenuate HBV infection.
Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.
PMID: 29384977 DOI: 10.1097/MD.0000000000009566
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