Ferrosenescence: the iron age of neurodegeneration?
Sfera A, Bullock K, Price A, Inderias L, Osorio C.
Mech Ageing Dev. 2017 Nov 24. pii: S0047-6374(17)30227-0. doi: 10.1016/j.mad.2017.11.012.
Abstract
Aging has been associated with iron retention in many cell types, including the neurons, promoting neurodegeneration by ferroptosis. Excess intracellular iron accelerates aging by damaging the DNA and blocking genomic repair systems, a process we define
as ferrosenescence. Novel neuroimaging and proteomic techniques have pinpointed indicators of both iron retention and ferrosenescence, allowing for their early correction, potentially bringing prevention of neurodegenerative disorders within reach. In
this review, we take a closer look at the early markers of iron dyshomeostasis in neurodegenerative disorders, focusing on preventive strategies based on nutritional and microbiome manipulations.
PMID: 29180225 DOI: 10.1016/j.mad.2017.11.012
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