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  • Iron In Palsy

    From ironjustice@21:1/5 to All on Mon Oct 23 12:22:03 2017
    Brain regional iron contents in progressive supranuclear palsy.
    Parkinsonism Relat Disord. 2017 Sep 28. pii: S1353-8020(17)30352-8. doi: 10.1016/j.parkreldis.2017.09.020.
    Lee SH1, Lyoo CH1, Ahn SJ2, Rinne JO3, Lee MS4.

    Abstract
    INTRODUCTION:
    To determine motor-related brain regions in which iron contents correlate with the degree of motor deficits of progressive supranuclear palsy (PSP).
    METHODS:
    Twenty-four patients with probable PSP and 20 controls were included. Using a 3.0T magnetic resonance imaging scanner, R2* values were measured in the putamen, globus pallidus (GP), substantia nigra (SN), subthalamic nucleus, and dentate nucleus. After
    adjustment for disease duration and age at examination, correlations between regional brain R2* values and Unified Parkinson Disease Rating Scale (UPDRS) total motor scores or subscores for bradykinesia, rigidity, tremor, or axial motor deficits were
    investigated.
    RESULTS:
    Compared to controls, patients with PSP had significantly higher R2* values in all of the five brain regions. UPDRS total motor scores and subscores for bradykinesia and axial motor deficits did not correlate with R2* values of the five brain regions.
    However, UPDRS subscores for unilateral rigidity were correlated with R2* values of the contralateral putamen and GP. In addition, unilateral UPDRS subscores for tremor were associated with R2* values of the ipsilateral dentate nucleus, contralateral
    putamen, GP, and SN.
    CONCLUSION:
    In PSP, excessive iron accumulation occurs in motor-related subcortical regions. Iron-related PSP pathologies in the lenticular nucleus are associated with rigidity severity, while those in the nigro-striato-pallidal unit and dentate nucleus are
    associated with tremor severity. Bradykinesia and axial motor deficits of PSP seem to be associated with widespread pathologies in the cerebrum, brainstem, cerebellum, as well as the basal ganglia.

    Copyright © 2017 Elsevier Ltd. All rights reserved.

    KEYWORDS:
    Basal ganglia; Iron; Progressive supranuclear palsy
    PMID: 28982612 DOI: 10.1016/j.parkreldis.2017.09.020

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