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  • Alpha-Linolenic Acid Against Adiposity

    From ironjustice@21:1/5 to All on Thu Sep 28 08:44:05 2017
    Diacylglycerol Enhances the Effects of Alpha-Linolenic Acid Against Visceral Fat: A Double-Blind Randomized Controlled Trial.
    Obesity (Silver Spring). 2017 Oct;25(10):1667-1675. doi: 10.1002/oby.21938. Epub 2017 Aug 29.
    Saito S1, Mori A2, Osaki N1, Katsuragi Y1.
    Author information
    Abstract
    OBJECTIVE:
    To investigate the effect of alpha-linolenic acid-rich diacylglycerol (ALA-DAG) compared with alpha-linolenic acid-rich triacylglycerol (ALA-TAG) on visceral fat area (VFA) in people with overweight.
    METHODS:
    Subjects with overweight were recruited to a randomized, double-blind, controlled, parallel-group designed trial and randomly allocated to two groups that consumed either 2.5 g/d ALA-TAG or ALA-DAG for 12 weeks. Two 4-week nontreatment periods were
    placed before and after the treatment period. One hundred fourteen subjects (n = 57 in the ALA-TAG group, n = 57 in the ALA-DAG group) were enrolled into the analysis set for efficacy evaluation.
    RESULTS:
    The VFA and BMI were significantly decreased by the ALA-DAG treatment with a treatment-by-time interaction compared with the ALA-TAG treatment (P < 0.05). Additionally, the change from baseline of the fasting serum TAG concentration at week 12 was
    significantly decreased by ALA-DAG treatment compared with ALA-TAG treatment (P < 0.05). Safety parameters such as urinary measurements, hematologic parameters and blood biochemistry, and the incidence of adverse events did not differ significantly
    between groups, and no ALA-DAG-associated adverse effects were detected. CONCLUSIONS:
    Incorporation of ALA-DAG in a regular diet for 12 weeks may lead to a reduction in VFA, BMI, and serum TAG in men and women with overweight.
    © 2017 The Authors. Obesity published by Wiley Periodicals, Inc. on behalf of The Obesity Society (TOS).

    PMID: 28851088 DOI: 10.1002/oby.21938

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