• Sesamol and Iron Overload

    From ironjustice@21:1/5 to All on Fri Aug 11 21:14:30 2023
    Sesamol Mitigates Chronic Iron Overload-Induced Cognitive Impairment and Systemic Inflammation via IL-6 and DMT1 Regulation
    Yajie Wang, Yuyu Zhang, Xinyu Wang, Qingyuan Li, Yu Zhao, Yishan Jiang, Rui Guo, Xuebo Liu, Tian Yuan, Zhigang Liu
    First published: 14 July 2023 https://doi.org/10.1002/mnfr.202300012
    Excessive iron contributes to oxidative damage and cognitive decline in Alzheimer's disease. Sesamol, a compound in sesame oil that exhibits both anti-inflammatory and neuroprotective properties, is examined in this study for its ability to alleviate
    cognitive impairments in iron overload mice model.

    Methods and results
    An iron overload model is established by intraperitoneally injecting dextran iron (250 mg kg−1 body weight) twice a week for 6 weeks, while sesamol (100 mg kg−1 body weight) is administered daily for the same length of time. The results demonstrate
    that sesamol protects spatial working memory and learning ability in iron overload mice, and inhibits neuronal loss and brain atrophy induced by iron overload. Moreover, sesamol significantly decreases interleukin-6 and malondialdehyde, and increases
    glutathione peroxidase 4 in the brains of iron overload mice. Additionally, sesamol maintains iron homeostasis in the brain by regulating the expressions of transferrin receptors, divalent metal transporter 1, and hepcidin, and reducing iron accumulation.
    Furthermore, sesamol suppresses disturbed systemic iron homeostasis and inflammation, particularly liver interleukin-6 expression.

    These findings suggest that sesamol may be effective in mitigating neuroinflammatory responses and cognitive impairments induced by iron overload, potentially through its involvement in mediating the liver-brain axis.

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