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  • Alpha-Linolenic Acid In Traumatic Brain Injury

    From ironjustice@21:1/5 to All on Tue Aug 29 12:02:07 2017
    Alpha-Linolenic Acid Treatment Reduces the Contusion and Prevents the Development of Anxiety-Like Behavior Induced by a Mild Traumatic Brain Injury in Rats.
    Mol Neurobiol. 2017 Aug 26. doi: 10.1007/s12035-017-0732-y.
    Figueiredo TH1, Harbert CL1, Pidoplichko V1, Almeida-Suhett CP1, Pan H2, Rossetti K1, Braga MFM1, Marini AM3.

    Abstract
    Approximately, 1.7 million Americans suffer a TBI annually and TBI is a major cause of death and disability. The majority of the TBI cases are of the mild type and while most patients recover completely from mild TBI (mTBI) about 10% result in persistent
    symptoms and some result in lifelong disability. Anxiety disorders are the second most common diagnosis post-TBI. Of note, TBI-induced anxiety disorders are difficult to treat and remain a chronic condition suggesting that new therapies are needed.
    Previous work from our laboratory demonstrated that a mild TBI induced an anxiety-like phenotype, a key feature of the human condition, associated with loss of GABAergic interneurons and hyperexcitability in the basolateral amygdala (BLA) in rodents 7
    and 30 days after a controlled cortical impact (CCI) injury. We now confirm that animals display significantly increased anxiety-like behavior 30 days after CCI. The anxiety-like behavior was associated with a significant loss of GABAergic interneurons
    and significant reductions in the frequency and amplitude of spontaneous and miniature GABAA-receptor-mediated inhibitory postsynaptic currents (IPSCs) in the BLA. Significantly, subchronic treatment with alpha-linolenic acid (ALA) after CCI prevents the
    development of anxiety-like behavior, the loss of GABAergic interneurons, hyperexcitability in the BLA and reduces the impact injury. Taken together, administration of ALA after CCI is a potent therapy against the neuropathology and pathophysiological
    effects of mTBI in the BLA.

    KEYWORDS:
    Alpha-linolenic acid; Anxiety disorders; Controlled cortical impact; Rat; Traumatic brain injury

    PMID: 28844093 DOI: 10.1007/s12035-017-0732-y

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