• Iron In Cognition

    From ironjustice@21:1/5 to All on Sat Feb 12 22:05:20 2022
    Increased iron and oxidative stress are separately related to cognitive decline in elderly
    Elcin E Umur 1, Cagatay Oktenli, Serkan Celik, Fatih Tangi, Ozkan Sayan, Yavuz S Sanisoglu, Osman Ipcioglu, Hakan M Terekeci, Cihan Top, Selim Nalbant, Yasar Kucukardali
    Geriatr Gerontol Int
    . 2011 Oct;11(4):504-9. doi: 10.1111/j.1447-0594.2011.00694.x. Epub 2011 Mar 30.

    Aim: The aim of this study is to examine the relation between body iron, oxidative stress and cognitive function in elderly.

    Methods: Eighty-seven elderly residents from nursing homes were the subjects of our study. Cognitive status was screened by the Mini-Mental State Examination (MMSE). Of the 87 eligible subjects, 46 patients who obtained 24 or fewer points on the MMSE
    scale were considered as subjects with cognitive dysfunction. The control group consisted of 41 subjects who obtained more than 24 points on the MMSE. Routine biochemical analyses, parameters of iron metabolism, malondialdehyde (MDA) and glutathione
    peroxidase (GSH-Px) were determined in all subjects.

    Results: There were statistically significant increases in serum iron, transferrin saturation, ferritin and MDA levels; whereas there was a statistically significant decrease in serum GSH-Px enzyme activity and serum sodium levels in subjects with
    cognitive dysfunction. A significant negative correlation was found between serum iron, transferrin saturation, ferritin and MMSE score. There was a negative correlation between MMSE score and serum MDA; however, a positive significant correlation was
    found between MMSE score and both GSH-Px enzyme activity and serum sodium.

    Conclusion: Our study provides evidence of increased markers of iron deposition and oxidative stress in patients with cognitive dysfunction. It seems likely that these markers negatively affect the MMSE score. Interestingly, we did not find any
    correlation between the markers of iron deposition and oxidative stress. Future studies will be required to demonstrate whether diminishing iron and oxidative stress will enhance MMSE score and thereby ameliorate cognitive impairment.

    PMID: 21447135 DOI: 10.1111/j.1447-0594.2011.00694.x

    © 2011 Japan Geriatrics Society.

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