Trehalose improves traumatic brain injury-induced cognitive impairmentof the stable disaccharide trehalose, which is known to protect against oxidative stress, increase levels of chaperone molecules and enhance autophagy. Furthermore, trehalose has demonstrated neuroprotective properties in numerous animal models and has
Stuart D. Portbury, Dominic J. Hare, David I. Finkelstein, Paul A. Adlard PLOS x
Published: August 24, 2017
RESEARCH ARTICLE
https://doi.org/10.1371/journal.pone.0183683
Abstract
Traumatic brain Injury (TBI) is a significant cause of death and long-term disability for which there are currently no effective pharmacological treatment options. In this study then, we utilized a mouse model of TBI to assess the therapeutic potential
source are credited.
Citation: Portbury SD, Hare DJ, Finkelstein DI, Adlard PA (2017) Trehalose improves traumatic brain injury-induced cognitive impairment. PLoS ONE 12(8): e0183683. https://doi.org/10.1371/journal.pone.0183683
Editor: Stephan N. Witt, Louisiana State University Health Sciences Center, UNITED STATES
Received: June 7, 2017; Accepted: August 9, 2017; Published: August 24, 2017 Copyright: © 2017 Portbury et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and
Data Availability: All relevant data are within the paper.
Funding: P.A.A. is supported by an Australian Research Council Future Fellowship (FT120100030). D.J.H. is supported by an Australian Research Council Linkage Project with Agilent Technologies (LP140100095).
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