• Iron In COVID-19 Infection

    From ironjustice@21:1/5 to All on Fri Sep 3 14:52:46 2021
    Open Access Review
    Role of Iron Chelation and Protease Inhibition of Natural Products on COVID-19 Infection
    by Giuseppe Carota 1,†OrcID,Simone Ronsisvalle 2,†,Federica Panarello 2,Daniele Tibullo 1OrcID,Anna Nicolosi 3 and
    Giovanni Li Volti 1,*OrcID
    Section of Biochemistry, Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy
    Department of Drug Sciences, University of Catania, 95123 Catania, Italy Hospital Pharmacy Unit, Ospedale Cannizzaro, 95125 Catania, Italy
    These authors contributed equally to this paper.
    Academic Editor: Nicola Petrosillo
    J. Clin. Med. 2021, 10(11), 2306; https://doi.org/10.3390/jcm10112306
    Received: 15 April 2021 / Revised: 14 May 2021 / Accepted: 20 May 2021 / Published: 25 May 2021


    Although the epidemic caused by SARS-CoV-2 callings for international attention to develop new effective therapeutics, no specific protocol is yet available, leaving patients to rely on general and supportive therapies. A range of respiratory diseases,
    including pulmonary fibrosis, have been associated with higher iron levels that may promote the course of viral infection. Recent studies have demonstrated that some natural components could act as the first barrier against viral injury by affecting iron
    metabolism. Moreover, a few recent studies have proposed the combination of protease inhibitors for therapeutic use against SARS-CoV-2 infection, highlighting the role of viral protease in virus infectivity. In this regard, this review focuses on the
    analysis, through literature and docking studies, of a number of natural products able to counteract SARS-CoV-2 infection, acting both as iron chelators and protease inhibitors. View Full-Text
    Keywords: SARS-Cov-2; COVID-19; iron chelation; protease inhibition; natural products

    Who loves ya.

    Jesus Was A Vegetarian!

    Man Is A Herbivore!


    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)