Open Access Review
Role of Iron Chelation and Protease Inhibition of Natural Products on COVID-19 Infection
by Giuseppe Carota 1,†OrcID,Simone Ronsisvalle 2,†,Federica Panarello 2,Daniele Tibullo 1OrcID,Anna Nicolosi 3 and
Giovanni Li Volti 1,*OrcID
Section of Biochemistry, Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy
Department of Drug Sciences, University of Catania, 95123 Catania, Italy Hospital Pharmacy Unit, Ospedale Cannizzaro, 95125 Catania, Italy
These authors contributed equally to this paper.
Academic Editor: Nicola Petrosillo
J. Clin. Med. 2021, 10(11), 2306;
https://doi.org/10.3390/jcm10112306
Received: 15 April 2021 / Revised: 14 May 2021 / Accepted: 20 May 2021 / Published: 25 May 2021
https://www.mdpi.com/2077-0383/10/11/2306
Abstract
Although the epidemic caused by SARS-CoV-2 callings for international attention to develop new effective therapeutics, no specific protocol is yet available, leaving patients to rely on general and supportive therapies. A range of respiratory diseases,
including pulmonary fibrosis, have been associated with higher iron levels that may promote the course of viral infection. Recent studies have demonstrated that some natural components could act as the first barrier against viral injury by affecting iron
metabolism. Moreover, a few recent studies have proposed the combination of protease inhibitors for therapeutic use against SARS-CoV-2 infection, highlighting the role of viral protease in virus infectivity. In this regard, this review focuses on the
analysis, through literature and docking studies, of a number of natural products able to counteract SARS-CoV-2 infection, acting both as iron chelators and protease inhibitors. View Full-Text
Keywords: SARS-Cov-2; COVID-19; iron chelation; protease inhibition; natural products
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