• Iron In Bacterial Resistance

    From ironjustice@21:1/5 to All on Sat Apr 13 18:01:47 2019
    Bacterial Resistance in Pneumonia in Developing Countries-A Role for Iron Chelation.
    Islam S1, Chisti MJ2, Ahmed M3, Anwar N4, Lehmann C5.
    Trop Med Infect Dis. 2019 Apr 10;4(2). pii: E59.
    doi: 10.3390/tropicalmed4020059.

    Pneumonia represents one of the major infectious diseases in developing countries and is associated with high mortality, in particular in children under the age of five. The main causative bacterial agents are Streptococcus pneumoniae and Haemophilus
    influenzae type B, accounting for 33% and 16%, respectively, of the mortality in under-fives. Iron modulates the immune response in infectious diseases and increased iron levels can lead to complications such as sepsis and multiorgan failure. This review
    will look into the use of iron chelators in order to reduce microbial growth and attenuate a dysregulated immune response during infection. Our hypothesis is that temporary restriction of iron will lessen the incidence and complication rate of infections
    like pneumonia and result in a decrease of mortality and morbidity.

    antibiotics; iron; iron chelation; pneumonia; resistance; sepsis

    PMID: 30974759 DOI: 10.3390/tropicalmed4020059

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