• Iron-chelating Epigallocatechin-3-gallate In Neurodegeneration

    From ironjustice@21:1/5 to All on Fri Aug 11 19:22:21 2017
    EGCG attenuates Fe(III)-induced conformational transition of α-synuclein and protects AS-PC12 cells against Fe(III)-induced death.
    J Neurochem. 2017 Aug 9. doi: 10.1111/jnc.14142.
    Zhao J1, Xu L1, Liang Q2,3, Sun Q1, Chen C1, Zhang Y3, Ding Y2,3, Zhou P1. Author information
    The fibrillation and aggregation of α-synuclein (AS), along with the conformational transition from random coil to β-sheet, are the critical steps in the development of Parkinson's disease (PD). It is acknowledged that iron accumulation in the brain
    may lead to the fibrillation of AS. However, (-)-epigallocatechin gallate (EGCG) can penetrate the blood-brain barrier, chelate metal ions and inhibit the fibrillation of amyloid proteins. Therefore, EGCG is warranted to be investigated for its potential
    to cure amyloid-related diseases. In present work, we sought to study the effects of EGCG on Fe(III)-induced fibrillation of AS on both molecular and cellular levels. We demonstrate that Fe(III) interacts with the amino residue of Tyr and Ala of AS, then
    accelerates the fibrillation of AS, and increases intracellular reactive oxygen species (ROS) in the AS transduced-PC12 cells (AS-PC12 cells). Whereas EGCG significantly inhibits this process by chelating Fe(III) and protects AS-PC12 cells against the
    toxicity induced by ROS and β-sheet-enriched AS fibrils. These findings yield useful information that EGCG might be a promising drug to prevent and treat the neurodegenerative diseases. This article is protected by copyright. All rights reserved.
    This article is protected by copyright. All rights reserved.

    EGCG ; Fe(III); PC12 cells; Parkinson's disease; α-synuclein
    PMID: 28792609 DOI: 10.1111/jnc.14142


    "EGCG exhibited potent iron-chelating activity comparable to that of the prototype iron chelator desferrioxamine"


    "Epigallocatechin-3-gallate and Epicatechin-3-gallate from Green Tea Decrease Plasma Non-Transferrin Bound Iron and Erythrocyte Oxidative Stress"


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