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  • Trichotillomania

    From ironjustice@21:1/5 to All on Fri Jan 4 07:02:19 2019
    A Pilot Examination of Oxidative Stress in Trichotillomania.
    Grant JE1, Chamberlain SR2.
    Psychiatry Investig. 2018 Dec;15(12):1130-1134.
    doi: 10.30773/pi.2018.09.07.1. Epub 2018 Dec 7.
    Abstract
    OBJECTIVE:
    Trichotillomania is a relatively common illness whose neurobiology is poorly understood. One treatment for adult trichotillomania, n-acetyl cysteine (NAC), has antioxidative properties, as well as effects on central glutamatergic transmission.
    Preclinical models suggest that excessive oxidative stress may be involved in its pathophysiology.

    METHODS:
    Adults with trichotillomania provided a blood sample for analysis of compounds that may be influenced by oxidative stress [glutathione, angiotensin II, ferritin, iron, glucose, insulin and insulin growth factor 1 (IGF1), and hepcidin]. Participants were
    examined on symptom severity, disability, and impulsivity. The number of participants with out-of-reference range oxidative stress measures were compared against the null distribution. Correlations between oxidative stress markers and clinical measures
    were examined.

    RESULTS:
    Of 14 participants (mean age 31.2 years; 92.9% female), 35.7% (n=5) had total glutathione levels below the reference range (p= 0.041). Other oxidative stress measures did not have significant proportions outside the reference ranges. Lower levels of
    glutathione correlated significantly with higher motor impulsiveness (Barratt Impulsiveness Scale sub-score) (r=0.97, p=0.001).

    CONCLUSION:
    A third of patients with trichotillomania had low levels of glutathione, and lower levels of glutathione correlated significantly with higher motor impulsiveness. Because NAC is a precursor for cysteine, and cysteine is a rate limiting step for
    glutathione production, these results may shed light on the mechanisms through which NAC can have beneficial effects for impulsive symptoms. Confirmation of these results requires a suitable larger follow-up study, including an internal normative control
    group.

    KEYWORDS:
    Glutathione; Obsessive-compulsive; Oxidative stress; Trichotillomania

    PMID: 30602106 DOI: 10.30773/pi.2018.09.07.1
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