• Trichotillomania

    From ironjustice@21:1/5 to All on Fri Jan 4 07:02:19 2019
    A Pilot Examination of Oxidative Stress in Trichotillomania.
    Grant JE1, Chamberlain SR2.
    Psychiatry Investig. 2018 Dec;15(12):1130-1134.
    doi: 10.30773/pi.2018.09.07.1. Epub 2018 Dec 7.
    Trichotillomania is a relatively common illness whose neurobiology is poorly understood. One treatment for adult trichotillomania, n-acetyl cysteine (NAC), has antioxidative properties, as well as effects on central glutamatergic transmission.
    Preclinical models suggest that excessive oxidative stress may be involved in its pathophysiology.

    Adults with trichotillomania provided a blood sample for analysis of compounds that may be influenced by oxidative stress [glutathione, angiotensin II, ferritin, iron, glucose, insulin and insulin growth factor 1 (IGF1), and hepcidin]. Participants were
    examined on symptom severity, disability, and impulsivity. The number of participants with out-of-reference range oxidative stress measures were compared against the null distribution. Correlations between oxidative stress markers and clinical measures
    were examined.

    Of 14 participants (mean age 31.2 years; 92.9% female), 35.7% (n=5) had total glutathione levels below the reference range (p= 0.041). Other oxidative stress measures did not have significant proportions outside the reference ranges. Lower levels of
    glutathione correlated significantly with higher motor impulsiveness (Barratt Impulsiveness Scale sub-score) (r=0.97, p=0.001).

    A third of patients with trichotillomania had low levels of glutathione, and lower levels of glutathione correlated significantly with higher motor impulsiveness. Because NAC is a precursor for cysteine, and cysteine is a rate limiting step for
    glutathione production, these results may shed light on the mechanisms through which NAC can have beneficial effects for impulsive symptoms. Confirmation of these results requires a suitable larger follow-up study, including an internal normative control

    Glutathione; Obsessive-compulsive; Oxidative stress; Trichotillomania

    PMID: 30602106 DOI: 10.30773/pi.2018.09.07.1
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