• Iron In Insomnia

    From ironjustice@21:1/5 to All on Tue Dec 18 13:08:02 2018
    Brain iron deposition in primary insomnia-An in vivo susceptibility-weighted imaging study.
    Chen L1, Wei X2, Liu C2, Li C3, Zhou Z4.
    Brain Behav. 2018 Dec 11:e01138. doi: 10.1002/brb3.1138.
    To study the brain iron deposition and its relationships with cognitive impairment and sleep quality in primary insomnia (PI).

    Thirty-five patients with PI and 35 volunteers underwent MRI scanning using high-resolution susceptibility-weighted imaging sequence. Bilateral anterior cingulate cortices, posterior cingulate cortex, hippocampus, caudate nucleus, globus pallidus,
    putamen, thalamus, red nucleus, substantia nigra, parietal cortex, and frontal white matter were selected as regions of interest. The phase shift values of the above areas were compared between the two groups. Partial correlations between phase shifts
    values and neuropsychological scale scores including Pittsburgh Sleep Quality Index, Insomnia Severity Index, Mini Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Activities of Daily Living Scale, and Clinical Dementia Rating of
    the PI patients were analyzed.

    Compared with the normal controls, the PI patients showed significant lower MMSE and MoCA scores and increased phase shift values in the left caudate nucleus, left putamen, left hippocampus, and bilateral thalamus (p < 0.05). Close correlation was found
    between the phase shift value of the left hippocampus and the MMSE scores of the PI patients (R = -0.447, p < 0.01).

    The PI patients exhibited significant cognitive impairment and increased iron deposition in several brain regions. The iron concentration of the left hippocampus is a biomarker of cognitive impairment and may play an important role in the
    pathophysiological mechanism.

    © 2018 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.

    MRI; cognitive impairment; iron deposition; primary insomnia

    PMID: 30548431 DOI: 10.1002/brb3.1138

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