• Iron in South Asians

    From ironjustice@21:1/5 to All on Fri Dec 14 14:44:16 2018
    Ferritin as a Risk Factor for Glucose Intolerance amongst Men and Women Originating from the Indian Subcontinent
    International Journal of Endocrinology
    Volume 2015, Article ID 924387, 6 pages
    Research Article
    Elizabeth A. Hughes,1 Jeetesh V. Patel,1,2 Zosia Bredow,2 Paramjit S. Gill,3 Julia Chackathayil,3 Elif S. Agaoglu,2 Paul Flinders,2 and Rebecca Mirrielees2
    1University of Birmingham Centre for Cardiovascular Sciences, Sandwell and West Birmingham Hospitals NHS Trust, West Midlands B18 7QH, UK
    2Medical School, University of Nottingham, Nottingham NG7 2UH, UK
    3Primary Care Clinical Sciences, University of Birmingham, West Midlands B15 2TT, UK
    Received 12 June 2015; Accepted 22 July 2015

    Background. Serum ferritin predicts the onset of diabetes; however, this relationship is not clear amongst South Asians, a population susceptible to glucose intolerance and anaemia. Objective. This study tests whether ferritin levels reflect glucose
    tolerance in South Asians, independent of lifestyle exposures associated with Indian or British residence. Methods. We randomly sampled 227 Gujaratis in Britain (49.8 (14.4) years, 50% men) and 277 contemporaries living in Gujarati villages (47.6 (11.8)
    years, 41% men). Both groups underwent a 75 g oral-glucose-tolerance test. We evaluated lifestyle parameters with standardised questionnaires and conducted comprehensive clinical and lab measurements. Results. Across sites, the age-adjusted prevalence
    of diabetes was 9.8%. Serum ferritin was higher amongst diabetics (), irrespective of site, gender, and central obesity (), and was associated with fasting and postchallenge glucose, anthropometry, blood pressure, triglycerides, and nonesterified fatty
    acids (). Diabetes was less in those with low ferritin (<20 mg/mL), , and risk estimate = 0.35 (95% CI 0.15–0.81), as were blood pressure and metabolic risk factors. On multivariate analysis, diabetes was independently associated with ferritin () and
    age ().
    Conclusion. Ferritin levels are positively associated with glucose intolerance in our test groups, independent of gender and Indian or UK lifestyle factors.

    Academic Editor: Javier Salvador

    Copyright © 2015 Elizabeth A. Hughes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly

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