• Nuts In Fertility

    From ironjustice@21:1/5 to All on Tue Dec 11 16:01:53 2018
    Effect of nut consumption on semen quality and functionality in healthy men consuming a Western-style diet: a randomized controlled trial
    The American Journal of Clinical Nutrition, American Society for Nutrition Albert Salas-Huetos Rocío Moraleda Simona Giardina Ester Anton Joan Blanco Jordi Salas-Salvadó Mònica Bulló
    The American Journal of Clinical Nutrition, Volume 108, Issue 5, 1 November 2018, Pages 953–962, https://doi.org/10.1093/ajcn/nqy181
    Published: 23 November 2018

    ABSTRACT
    Background
    Human semen quality has declined in industrialized countries. Pollution, smoking, and the consumption of a Western-style diet are all hypothesized as potential causes.

    Objective
    We evaluated the effect of chronic consumption of nuts on changes in conventional semen parameters and the potential mechanisms implicated.

    Design
    The FERTINUTS study was a 14-wk randomized, controlled, parallel trial. A total of 119 healthy men, aged 18–35 y, were allocated to 1 of 2 intervention groups: one group was fed the usual Western-style diet enriched with 60 g of a mixture of nuts/d (
    nut group), and the other was fed the usual Western-style diet avoiding nuts (control group). Semen and blood samples were collected at baseline and at the end of the intervention. Dietary information was recorded throughout the trial. Changes in
    conventional semen parameters (pH, volume, sperm count and concentration, motility, and morphology) were determined as primary outcomes. The effect of nut consumption on sperm DNA fragmentation (SDF), reactive oxygen species (ROS) production, chromosome
    anomalies (X, Y, and 18), total DNA methylation, and microRNA expression were measured in sperm samples as potential causes of the changes in the seminogram.

    Results
    Compared with the control group, improvements in total sperm count (P = 0.002) and vitality (P = 0.003), total motility (P = 0.006), progressive motility (P = 0.036), and morphology of sperm (P = 0.008) were observed in the nut group. Participants in the
    nut group showed an increase in the consumption of total fat, monounsaturated fatty acids, polyunsaturated fatty acids, magnesium, vitamin E, α-linolenic acid, total omega-3 (n–3) and ω-3:ω-6 ratio intake during the intervention. Participants in the
    nut group showed a significant reduction in SDF (P < 0.001) and in the expression of hsa-miR-34b-3p (P = 0.036). No significant changes in ROS, sperm chromosome anomalies, or DNA methylation were observed between groups.

    Conclusions
    The inclusion of nuts in a Western-style diet significantly improves the total sperm count and the vitality, motility, and morphology of the sperm. These findings could be partly explained by a reduction in the sperm DNA fragmentation. This trial was
    registered at ISRCTN as ISRCTN12857940.

    randomized clinical trial, Western-style diet, nuts, semen quality, sperm DNA fragmentation
    Issue Section: Original Research Communications
    © 2018 American Society for Nutrition.

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