• Iron In Parkinson's Progression Prevention

    From ironjustice@21:1/5 to All on Mon Jul 23 20:06:58 2018
    Prevention of progression in Parkinson's disease.
    Aaseth J1,2, Dusek P3,4,5, Roos PM6,7.
    Biometals. 2018 Jul 20. doi: 10.1007/s10534-018-0131-5.
    Environmental influences affecting genetically susceptible individuals seem to contribute significantly to the development of Parkinson's disease (PD). Xenobiotic exposure including transitional metal deposition into vulnerable CNS regions appears to
    interact with PD genes. Such exposure together with mitochondrial dysfunction evokes a destructive cascade of biochemical events, including oxidative stress and degeneration of the sensitive dopamine (DA) production system in the basal ganglia. Recent
    research indicates that the substantia nigra degeneration can be decelerated by treatment with iron binding compounds such as deferiprone. Interestingly compounds known to decrease PD risk including caffeine, niacin, nicotine and salbutamol also possess
    iron binding properties. Adequate function of antioxidative mechanisms in the vulnerable brain cells can be restored by acetylcysteine supplementation to normalize intracellular glutathione activity. Other preventive measures to reduce deterioration of
    dopaminergic neurons may involve life-style changes such as intake of natural antioxidants and physical exercise. Further research is recommended to identify therapeutic targets of the proposed interventions, in particular protection of the DA
    biosynthesis by oxygen radical scavengers and iron binding agents.

    Copper; Dopamine; Iron; Metal binding; Oxidative stress; Substantia nigra

    PMID: 30030679 DOI: 10.1007/s10534-018-0131-5

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