High serum iron markers are associated with periodontitis in postmenopausal women: a population-based study (NHANES III)
Susilena Arouche Costa 1, Cecilia Claudia Costa Ribeiro 2, Ana Regina Oliveira Moreira 3, Soraia de Fátima Carvalho Souza 4
J Clin Periodontol
. 2021 Dec 8. doi: 10.1111/jcpe.13580.\

Abstract
Aim: To investigate the association between increased serum markers of iron (ferritin and transferrin saturation) and the severity and extent of periodontitis in postmenopausal women.

Methods: Data from 982 postmenopausal women participating in NHANES III were analyzed. Exposures were high ferritin (≥ 300 μg/mL) and transferrin saturation (≥45%). The primary outcome was moderate/severe periodontitis defined according to Centers
for Disease Control and Prevention and the American Academy of Periodontology. The extent of periodontitis was also assessed as outcome: proportion of sites affected by clinical attachment loss ≥4 mm and probing depth ≥ 4 mm. Crude and adjusted
Prevalence Ratio (PR) and Mean Ratio (MR) were estimated using Poisson Regression.

Results: The prevalence of moderate/severe periodontitis was 27.56%. High ferritin was associated with moderate/severe periodontitis in the crude (PR 1.55, p = 0.018) and in the final adjusted model (PR 1.53, p = 0.008). High ferritin and transferrin
saturation levels were associated with a higher proportion of sites with clinical attachment loss ≥4 mm (p < 0.05).

Conclusion: The increasing serum iron markers seem to contribute to periodontitis severity and extent in postmenopausal women.

PMID: 34879443 DOI: 10.1111/jcpe.13580

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh

Man Is A Herbivore!
http://tinyurl.com/4rq595

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

--- SoupGate-Win32 v1.05
* Origin: fsxNet Usenet Gateway (21:1/5)

On 12/9/2021 3:47 AM, tom hennessy wrote:

High serum iron markers are associated with periodontitis in postmenopausal women: a population-based study (NHANES III)
Susilena Arouche Costa 1, Cecilia Claudia Costa Ribeiro 2, Ana Regina Oliveira Moreira 3, Soraia de Fátima Carvalho Souza 4
J Clin Periodontol
. 2021 Dec 8. doi: 10.1111/jcpe.13580.\

Abstract
Aim: To investigate the association between increased serum markers of iron (ferritin and transferrin saturation) and the severity and extent of periodontitis in postmenopausal women.

Methods: Data from 982 postmenopausal women participating in NHANES III were analyzed. Exposures were high ferritin (≥ 300 μg/mL) and transferrin saturation (≥45%). The primary outcome was moderate/severe periodontitis defined according to Centers

for Disease Control and Prevention and the American Academy of Periodontology. The extent of periodontitis was also assessed as outcome: proportion of sites affected by clinical attachment loss ≥4 mm and probing depth ≥ 4 mm. Crude and adjusted
Prevalence Ratio (PR) and Mean Ratio (MR) were estimated using Poisson Regression.

Results: The prevalence of moderate/severe periodontitis was 27.56%. High ferritin was associated with moderate/severe periodontitis in the crude (PR 1.55, p = 0.018) and in the final adjusted model (PR 1.53, p = 0.008). High ferritin and transferrin

saturation levels were associated with a higher proportion of sites with clinical attachment loss ≥4 mm (p < 0.05).

Conclusion: The increasing serum iron markers seem to contribute to periodontitis severity and extent in postmenopausal women.

PMID: 34879443 DOI: 10.1111/jcpe.13580

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh

Man Is A Herbivore!
http://tinyurl.com/4rq595

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

1) Increase in ferritin has potential causes other than diet
2) Association does not indicate causation.

--- SoupGate-Win32 v1.05
* Origin: fsxNet Usenet Gateway (21:1/5)

Steven Bornfeld <dentaltwin@earthlink.net> wrote:

On 12/9/2021 3:47 AM, tom hennessy wrote:

High serum iron markers are associated with periodontitis in
postmenopausal women: a population-based study (NHANES III)
Susilena Arouche Costa 1, Cecilia Claudia Costa Ribeiro 2,
Ana Regina Oliveira Moreira 3, Soraia de F??tima Carvalho Souza 4
J Clin Periodontol . 2021 Dec 8. doi: 10.1111/jcpe.13580.\

Abstract
Aim: To investigate the association between increased serum markers
of iron (ferritin and transferrin saturation) and the severity and
extent of periodontitis in postmenopausal women.

Methods: Data from 982 postmenopausal women participating in
NHANES III were analyzed. Exposures were high ferritin (300 g/mL)
and transferrin saturation (45%). The primary outcome was
moderate/severe periodontitis defined according to Centers for
Disease Control and Prevention and the American Academy of
Periodontology. The extent of periodontitis was also assessed
as outcome: proportion of sites affected by clinical attachment
loss 4mm and probing depth 4mm. Crude and adjusted Prevalence
Ratio (PR) and Mean Ratio (MR) were estimated using Poisson
Regression.

Results: The prevalence of moderate/severe periodontitis was 27.56%.
High ferritin was associated with moderate/severe periodontitis in
the crude (PR 1.55, p = 0.018) and in the final adjusted model
(PR 1.53, p = 0.008). High ferritin and transferrin saturation levels
were associated with a higher proportion of sites with clinical
attachment loss 4mm (p < 0.05).

Conclusion: The increasing serum iron markers seem to contribute
to periodontitis severity and extent in postmenopausal women.

PMID: 34879443 DOI: 10.1111/jcpe.13580
Tom

1) Increase in ferritin has potential causes other than diet
2) Association does not indicate causation.

Actually, re item 2, it kind of does. Not direct A-->B causation,
but indirect C-->A && C-->B, i.e., a (so far undetected) common
cause for both A and B. The typical paradigmatic example given
is the 100% correlation between the monsoon season in India,
which always begins several weeks after flowers bloom in upstate
New York. So NY flowers cause India's monsoons? No, but the Earth's
orbit around the Sun causes both. So the point here would be to
suggest that maybe (emphasize maybe) whatever (besides diet, as per
your item 1) is causing ferritin increase might also be responsible
for the periodontitis increase. At least, might be worth looking at.
--
John Forkosh ( mailto: j@f.com where j=john and f=forkosh )

--- SoupGate-Win32 v1.05
* Origin: fsxNet Usenet Gateway (21:1/5)

On 12/10/2021 3:12 AM, John Forkosh wrote:

1) Increase in ferritin has potential causes other than diet
2) Association does not indicate causation.

Actually, re item 2, it kind of does. Not direct A-->B causation,
but indirect C-->A && C-->B, i.e., a (so far undetected) common
cause for both A and B. The typical paradigmatic example given
is the 100% correlation between the monsoon season in India,
which always begins several weeks after flowers bloom in upstate
New York. So NY flowers cause India's monsoons? No, but the Earth's
orbit around the Sun causes both. So the point here would be to
suggest that maybe (emphasize maybe) whatever (besides diet, as per
your item 1) is causing ferritin increase might also be responsible
for the periodontitis increase. At least, might be worth looking at.

Hi John, hope all is well.
You are correct of course. I might better have said that correlation
does not NECESSARILY mean causation (or not the direction of causation.
A direct cause of high ferritin might be hemochromatosis.
Hemochromatosis is often undiagnosed. My late wife had hemochromatosis,
she definitely did NOT have periodontitis. Has that study been done? Apparently yes!

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195524/

--- SoupGate-Win32 v1.05
* Origin: fsxNet Usenet Gateway (21:1/5)

Steven Bornfeld <dentaltwin@earthlink.net> wrote:

John Forkosh wrote:

1) Increase in ferritin has potential causes other than diet
2) Association does not indicate causation.

Actually, re item 2, it kind of does. Not direct A-->B causation,
but indirect C-->A && C-->B, i.e., a (so far undetected) common
cause for both A and B. The typical paradigmatic example given
is the 100% correlation between the monsoon season in India,
which always begins several weeks after flowers bloom in upstate
New York. So NY flowers cause India's monsoons? No, but the Earth's
orbit around the Sun causes both. So the point here would be to
suggest that maybe (emphasize maybe) whatever (besides diet, as per
your item 1) is causing ferritin increase might also be responsible
for the periodontitis increase. At least, might be worth looking at.

Hi John, hope all is well.

So far, so good (quoting the captain of the Titanic).

You are correct of course.

I didn't mean (and wouldn't have posted) to correct you, per se.
Just wanted to suggest that the op's observation might possibly
be of some value.

I might better have said that correlation
does not NECESSARILY mean causation (or not the direction of causation.
A direct cause of high ferritin might be hemochromatosis.
Hemochromatosis is often undiagnosed. My late wife had hemochromatosis,
she definitely did NOT have periodontitis. Has that study been done? Apparently yes!

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195524/

Thanks for the link. Too many multi-syllable words I wasn't
familiar with to make a whole lot of sense out of it, but that final
paragraph preceding _Results_, "Therefore, we hypothesized that..."
seems to suggest (as far as I could infer) that they're taking the
correlation seriously, i.e., as meaning something more than
coincidence.
--
John Forkosh ( mailto: j@f.com where j=john and f=forkosh )

--- SoupGate-Win32 v1.05
* Origin: fsxNet Usenet Gateway (21:1/5)