• Exactly one reference to Vitale Thine at Pub Med

    From bv.21.tv@gmail.com@21:1/5 to Joel M. Eichen on Sun Mar 22 04:54:12 2020
    On Tuesday, September 4, 2001 at 8:52:12 AM UTC+5:30, Joel M. Eichen wrote:
    1: Cancer Res 1994 Nov 1;54(21):5623-5635Related Articles, Books, LinkOut


    Vitalethine modulates erythropoiesis and neoplasia.

    Knight GD, Laubscher KH, Fore ML, Clark DA, Scallen TJ.

    School of Medicine, University of New Mexico, Albuquerque 87131.

    Novel compounds based upon the thiol N-(carboxy)-beta-alanyl-cysteamine (vitaletheine) have strikingly potent and seemingly diverse biological activities. Concentrations of vitaletheine modulators from 1 femtograms/ml
    to 100 picograms/ml medium regulate RBC production from progenitors
    initially deprived of erythropoietin. Similarly, as little as attograms/ml concentrations of the disulfide vitalethine stimulate immunological
    responses of murine splenocytes toward sheep RBC in a hemolytic plaque
    assay. Because dosages of vitalethine as low as femtograms/kg substantially diminish tumor size and incidence and increase survival to 80% in mice inoculated with a uniformly fatal melanoma (Cloudman S-91), activities of these compounds have in vivo significance. A preliminary probe of the benzyl derivative of vitalethine in a myeloma model (NS-1) suggests efficacy (100% survival) as well. The high potencies of the vitaletheine modulators, both
    in cell culture and in vivo, indicate that these or similar regulatory components, if constitutively present, probably occur endogenously at vanishingly small concentrations and may be prone to deficiency resulting from metabolic imbalances, irradiation, aging, diet, pathogenic or parasitic infections, or exposure to environmental pollutants. Pathways for the biosynthesis of vitaletheine are proposed and chemical syntheses of the vitaletheine modulators are described. Possible molecular mechanisms of action, including interactions with peptidyl hormones, other endogenous effectors, and xenobiotic and pharmaceutical compounds, are explored. Indications for the treatment of other diseases are identified.

    PMID: 7923208 [PubMed - indexed for MEDLINE]


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