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https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00171-3/fulltext
Shorter link:
https://tinyurl.com/COVID042424
<begin ABSTRACT>
Background
Growing evidence suggests that symptoms associated with post-COVID-19
condition (also known as long COVID) can affect multiple organs and
systems in the human body, but their association with viral
persistence is not clear. The aim of this study was to investigate the persistence of SARS-CoV-2 in diverse tissues at three timepoints
following recovery from mild COVID-19, as well as its association with
long COVID symptoms.
Methods
This single-centre, cross-sectional cohort study was done at
China–Japan Friendship Hospital in Beijing, China, following the
omicron wave of COVID-19 in December, 2022. Individuals with mild
COVID-19 confirmed by PCR or a lateral flow test scheduled to undergo gastroscopy, surgery, or chemotherapy, or scheduled for treatment in
hospital for other reasons, at 1 month, 2 months, or 4 months after
infection were enrolled in this study. Residual surgical samples,
gastroscopy samples, and blood samples were collected approximately 1
month (18–33 days), 2 months (55–84 days), or 4 months (115–134 days)
after infection. SARS-CoV-2 was detected by digital droplet PCR and
further confirmed through RNA in-situ hybridisation,
immunofluorescence, and immunohistochemistry. Telephone follow-up was
done at 4 months post-infection to assess the association between the persistence of SARS-CoV-2 RNA and long COVID symptoms.
Findings
Between Jan 3 and April 28, 2023, 317 tissue samples were collected
from 225 patients, including 201 residual surgical specimens, 59
gastroscopy samples, and 57 blood component samples. Viral RNA was
detected in 16 (30%) of 53 solid tissue samples collected at 1 month,
38 (27%) of 141 collected at 2 months, and seven (11%) of 66 collected
at 4 months. Viral RNA was distributed across ten different types of
solid tissues, including liver, kidney, stomach, intestine, brain,
blood vessel, lung, breast, skin, and thyroid. Additionally,
subgenomic RNA was detected in 26 (43%) of 61 solid tissue samples
tested for subgenomic RNA that also tested positive for viral RNA. At
2 months after infection, viral RNA was detected in the plasma of
three (33%), granulocytes of one (11%), and peripheral blood
mononuclear cells of two (22%) of nine patients who were
immunocompromised, but in none of these blood compartments in ten
patients who were immunocompetent. Among 213 patients who completed
the telephone questionnaire, 72 (34%) reported at least one long COVID
symptom, with fatigue (21%, 44 of 213) being the most frequent
symptom. Detection of viral RNA in recovered patients was
significantly associated with the development of long COVID symptoms
(odds ratio 5·17, 95% CI 2·64–10·13, p<0·0001). Patients with higher
virus copy numbers had a higher likelihood of developing long COVID
symptoms.
Interpretation
Our findings suggest that residual SARS-CoV-2 can persist in patients
who have recovered from mild COVID-19 and that there is a significant association between viral persistence and long COVID symptoms. Further
research is needed to verify a mechanistic link and identify potential
targets to improve long COVID symptoms.
<end ABSTRACT>
Bottom line:
So let's always use #WTEC as shown at
http://WonderfullyHungry.org to
eradicate the COVID-19 virus now because #COVIDisNotOver.
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