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  • Iron In Shortened Telemores

    From ironjustice@21:1/5 to All on Fri Oct 23 11:02:38 2020
    LEUKOCYTE TELOMERE LENGTH IS ASSOCIATED WITH IRON OVERLOAD IN MALE ADULTS WITH HEREDITARY HEMOCHROMATOSIS
    Biosci Rep
    2020 Oct 7;BSR20201916. doi: 10.1042/BSR20201916.
    Maximiliano Martin 1, Andrea Millan 2, Florencia Ferraro 1, Walter Francisco Tetzlaff 3, Ezequiel Lozano Chiappe 1, Eliana Botta 1, Marcelo Castro 4, Laura Boero 1, Jorge Rey 4, Jorge Daruich 4, Gustavo Frechtel 2, Tomas Merono 3, Gloria Cerrone 2,
    Fernando Brites 1
    PMID: 33026063 DOI: 10.1042/BSR20201916
    Free article
    Abstract
    Hereditary hemochromatosis (HH) is a primary iron overload (IO) condition. Absolute telomere length (ATL) is a marker of cellular aging and DNA damage associated with chronic diseases and mortality.
    Aim: To evaluate the relationship between ATL and IO in patients with HH. Methods: Cross-sectional study including25 patients with HH: 8 with IO and 17 without IO (ferritin< 300ng/ml) and 25 healthy controls.
    Inclusion criteria were: age>18 years, male sex and HH diagnosis. Patients with diabetes or other endocrine and autoimmune diseases were excluded. ATL was measured by real-time PCR.
    Results: HH patients with IO were older (p<0.001) and showed higher ferritin concentration (p<0.001). Patients with HH, disregarding the iron status, showed higher glucose and BMI than controls (both p<0.01). ATL was shorter in patients with IO than
    controls [with IO: 8 (6-14), without IO: 13 (9-20),and controls: 19 (15-25) kilobase pairs, p<0.01];with a linear trend within groups (p for trend<0.01). Differences in ATL remained statistically significant after adjusting by age, BMI and glucose(p<0.05)
    .
    Discussion: Patients with IO featured shorter ATL while patients without IO showed only mild alterations vs. controls. Screening for IO is encouraged to prevent iron-associated cellular damage and early telomere attrition.

    Keywords: Iron Metabolism; Iron Overload; Telomere Lenght.

    Copyright 2020 The Author(s).

    Who loves ya.
    Tom


    Jesus Was A Vegetarian!
    http://tinyurl.com/2r2nkh


    Man Is A Herbivore!
    http://tinyurl.com/a3cc3


    DEAD PEOPLE WALKING
    http://tinyurl.com/zk9fk

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)
  • From sciwiseg@gmail.com@21:1/5 to ironjustice on Mon Dec 21 14:13:38 2020
    On Saturday, October 24, 2020 at 7:02:39 AM UTC+13, ironjustice wrote:
    LEUKOCYTE TELOMERE LENGTH IS ASSOCIATED WITH IRON OVERLOAD IN MALE ADULTS WITH HEREDITARY HEMOCHROMATOSIS
    Biosci Rep
    2020 Oct 7;BSR20201916. doi: 10.1042/BSR20201916.
    Maximiliano Martin 1, Andrea Millan 2, Florencia Ferraro 1, Walter Francisco Tetzlaff 3, Ezequiel Lozano Chiappe 1, Eliana Botta 1, Marcelo Castro 4, Laura Boero 1, Jorge Rey 4, Jorge Daruich 4, Gustavo Frechtel 2, Tomas Merono 3, Gloria Cerrone 2,
    Fernando Brites 1
    PMID: 33026063 DOI: 10.1042/BSR20201916
    Free article
    Abstract
    Hereditary hemochromatosis (HH) is a primary iron overload (IO) condition. Absolute telomere length (ATL) is a marker of cellular aging and DNA damage associated with chronic diseases and mortality.
    Aim: To evaluate the relationship between ATL and IO in patients with HH. Methods: Cross-sectional study including25 patients with HH: 8 with IO and 17 without IO (ferritin< 300ng/ml) and 25 healthy controls.
    Inclusion criteria were: age>18 years, male sex and HH diagnosis. Patients with diabetes or other endocrine and autoimmune diseases were excluded. ATL was measured by real-time PCR.
    Results: HH patients with IO were older (p<0.001) and showed higher ferritin concentration (p<0.001). Patients with HH, disregarding the iron status, showed higher glucose and BMI than controls (both p<0.01). ATL was shorter in patients with IO than
    controls [with IO: 8 (6-14), without IO: 13 (9-20),and controls: 19 (15-25) kilobase pairs, p<0.01];with a linear trend within groups (p for trend<0.01). Differences in ATL remained statistically significant after adjusting by age, BMI and glucose(p<0.05)
    .
    Discussion: Patients with IO featured shorter ATL while patients without IO showed only mild alterations vs. controls. Screening for IO is encouraged to prevent iron-associated cellular damage and early telomere attrition.

    Keywords: Iron Metabolism; Iron Overload; Telomere Lenght.

    Copyright 2020 The Author(s).

    Who loves ya.
    Tom


    Jesus Was A Vegetarian!
    http://tinyurl.com/2r2nkh


    Man Is A Herbivore!
    http://tinyurl.com/a3cc3


    DEAD PEOPLE WALKING
    http://tinyurl.com/zk9fk


    And yet he fed many with loaves of bread and fish, if I remember rightly. You'd be hard pressed nowadays to find a piece of fish that wasn't contaminated with Mercury
    or dioxin or some other pathogen. Similarly most breads contain toxins.

    --- SoupGate-Win32 v1.05
    * Origin: fsxNet Usenet Gateway (21:1/5)